Drug Reactions

Question 1

coronary vasospasm

Answer 1

cocaine, sumatriptan

Question 2

cutaneous flushing

Answer 2

VANC: Vancomycin, Adenosine, Niacin, Ca channel blockers

Question 3

dilated cardiomyopathy

Answer 3

Doxorubicin, daunorubicin

Question 4

torsades de pointes

Answer 4

Class III (sotalol), class IA (quinidine) antiarrhythmics

Question 5

agranulocytosis

Answer 5

Clozapine, Carbamazepine, Colchicine, PTU, Methimazole, Dapsone
(Agranulocytosis Could Certainly Cause Pretty Major Damage)

Question 6

aplastic anemia

Answer 6

chloramphenicol, benzene, NSAIDs, PTU, methimazole

Question 7

direct Coombs-positive hemolytic anemia

Answer 7

methyldopa

Question 8

gray baby syndrome

Answer 8

chloramphenicol

Question 9

hemolysis in G6PD-deficient pts

Answer 9

Isoniazid (INH), sulfonamides, primaquine, aspirin, ibuprofen, nitrofurantoin
(Hemolysis IS PAIN)

Question 10

megaloblastic anemia

Answer 10

phenytoin, methotrexate, sulfa drugs

have a blast with PMS

Question 11

thrombotic complications

Answer 11

OCPs

Question 12

cough

Answer 12

ACE-I

Question 13

pulmonary fibrosis

Answer 13

BLeomycin, Amiodarone, Busulfan

it’s hard to BLAB when you have pulm fibrosis

Question 14

acute cholestatic hepatitis

Answer 14

erythromycin

Question 15

focal to massive hepatic necrosis

Answer 15

halothane, acetaminophen, valproic acid, Aamanita phalloides

liver HAVAc

Question 16

hepatitis

Answer 16

INH

Question 17

pseudomembranous colitis

Answer 17

clindamycin, ampicillin

Question 18

adrenocortical insufficiency

Answer 18

glucocorticoid withdrawal (HPA suppression)

Question 19

gynecomastia

Answer 19

Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole
(Some Drugs Create Awesome Knockers)

Question 20

hot flashes

Answer 20

tamoxifen, clomiphene

Question 21

hypothyroidism

Answer 21

lithium, amiodarone, sulfonamides

Question 22

hyperglycemia

Answer 22

niacin, tacrolimus, protease inhibitors

Question 23

fat redistribution

Answer 23

glucocorticoids, protease inhibitors

Question 24

gingival hyperplasia

Answer 24

phenytoin, verapamil

Question 25

gout

Answer 25

furosemide, thiazides, niacin, cyclosporine, pyrazinamide

Question 26

myopathies

Answer 26

Fibrates, Niacin, Colchicine, Hydroxychloroquine, Interferon alpha, Penicillamine, Statins, Glucocorticoids (Fish N CHIPS Give you myopathies)

Question 27

osteoporosis

Answer 27

corticosteroids, heparin

Question 28

photosensitivity

Answer 28

Sulfonadmides, Amiodarone, Tetracycline | SAT for a photo

Question 29

rash (Stevens-Johnson syndrome)

Answer 29

Penicillin, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigene, Allopurinol, Phenytoin, Phenobarbital (bad rash after a PEC SLAPP)

Question 30

SLE-like syndrome

Answer 30

hydralazine, INH, procainamide, phenytoin

Question 31

tendonitis, tendon rupture, cartilage damage (kids)

Answer 31

fluoroquinolones

Question 32

diabetes insipidus

Answer 32

lithium, demeclocycline

Question 33

fanconi's syndrome

Answer 33

expired tetracycline

Question 34

interstitial nephritis

Answer 34

methicillin, NSAIDs, furosemide

Question 35

hemorrhagic cystitis

Answer 35

cyclophosphamide, ifosfamide (prevent by coadministering with mesna)

Question 36

SIADH

Answer 36

carbamazepine, cyclophosphamide

Question 37

cinchonism (overdose)

Answer 37

quinidine, quinine

Question 38

parkinson-like syndrome

Answer 38

antipsychotics, reserpine, metoclopramide

Question 39

seizures

Answer 39

bupropion, imipenem/cilastatin, isoniazid

Question 40

tardive dyskinesia

Answer 40

antipsychotics

Question 41

antimuscarinic

Answer 41

atropine, TCAs, H1 blockers, neuroleptics

Question 42

disulfiram-like reaction

Answer 42

metronidazole, certain cephalosporins, procarbazine, 1st generation sulfonylureas

Question 43

nephrotoxicity/ototoxicity

Answer 43

aminoglycosides, vancomycin, loop diuretics, cisplatin