Flashcards in Drugs Deck (18):
Prevent the loss of bone mass, can be used in the treatment of osteoporosis.
Encourage osteoclasts to undergo apoptosis.
Causes depolarisation block. Opens the AChR but isn't degraded by AChE. Will inactivate sodium channels. Maintained depolarisation will fail to open adjacent sodium channels because they are inactivated.
In anaesthetics, inhibits acetylcholinesterase and is used to reverse the nicotinic receptor blockade.
Local anaesthetic, blocks the pore of sodium channels
Hydrophobic pathway - diffuses into the membrane, then blocks the receptor by moving laterally into it. Non use dependent.
Hydrophilic pathway - diffuses through the membrane and is activated by hydrogen ions. Then moves into the pore and blocks it. Use-dependent.
Used in cardiac arrest to restore function and anaphylaxic shock.
Beta 1 agonist
Given in cardiogenic shock to restore heart function
Beta 2 agonist for the treatment of asthma. Causes bronchodilation.
Alpha 1 antagonist.
Inhibits NA action on smooth muscle receptors causing vasodilation.
Slows the heart rate and force of contraction.
Also causes bronchoconstriction.
Slows heart rate and force of contraction
Treatment for glaucoma
Causes constriction of pupillary muscles, allowing aqueous humour to drain more quickly
Increases heart rate and bronchodilation
Used to dilate pupils for examination of the eye
Reversible anticholinesterases which are broken down much slower than acetylcholine so have relatively long lasting effects.
Used in treatment of myasthenia gravis, can reverse neuromuscular block.
Acetylcholine receptor antagonist, causes paralysis.
Cure using pyridostigmine.
Blocks L-type calcium channels
Lowers blood pressure and reduces angina.
Agonist deprivation or antagonist exposure which causes upregulation of receptors.
Method to reduce the responsiveness to the continuing or increasing dose of a drug
Explain homologous desensitisation
When a receptor reduces its response to a signalling molecule when that agonist is in high concentration.