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Pharm Unit 4 by Hans Kim > drugs for lipid lowering agents > Flashcards

Flashcards in drugs for lipid lowering agents Deck (15)
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1

why is HDL anti-atherogenic?

1. reverse cholesterol transport
2. protects against endothelial dysfunction
3. inhibits oxidative stress

2

what are the 5 classes of hypolipidemic agents?

1. nicotinic acid (niacin)
2. fibric acid derivatives (fibrates)
3. bile acid sequestrants (resins)
4. HMG-CoA reductase inhibitors (statins)
5. Ezetimibe (a new class of lipid lowering agent)

3

what does niacin do?

1. raises HDL
2. lowers TGs
3. lowers LDL

4

side effects of niacin?

1. hepatoxicity
2. hyperglycemia
3. hyperuricemia
4. flushing
5. pruritis
6. dyspepsia
7. rashes

5

what does fibric acid derivatives do?

1. reduction in VLDL
2. variable (but small) effects on LDL
3. 10% increase in HDL

6

what is the mech of fibrates?

effects are mediated by binding to PPARa

7

how does gemfibrozil work?

activation of lipoprotein lipase

8

what are bile acid sequestrants (resins)?

1. anion-exchange resins that bind bile acids in the intestines
2. are not absorbed, bound bile acids secreted in stool
3. decreases LDL but increases TGs
4. safe, but interferes with absorption of fat-soluble vitamines

9

what are statins?

1. most effective, best-tolerated
2. reduce LDL, VLDL
3. increase HDL

10

what are the adverse effects of statins?

1. hepatic dysfunction
2. myopathy

11

what are the two possible beneficial effects of statins?

1. counteract osteoporosis
2. cardioprotective

12

what is the new class of lipid lowering agent?

ezetimibe

13

what is the mech of ezetimibe?

inhibits both dietary and biliary cholesterol absorption in the intestine by blocking a sterol transporter on the enterocyte --> thus, it reduces the amount of cholesterol delivered to the liver

14

what are the effects of ezetimibe?

1. lowers LDL (synergistic with statins)
2. once a day pill
3. few side effects

15

both ezetimibe and simvastatin lowered LDL

by 52% at the starting dose