Flashcards in Diuretics 1 Deck (10)
total body fluids account for what % of the body weight?
60% (for 70kg person it's about 42L)
ICF is about what % of the body weight?
40% = 28L
ECF is about what % of body weight?
20% = 14L
blood pressure is
TPR X CO
cardiac output is
HR X SV
what is edema?
excess accumulation of fluid in the interstitial space due to cardiac, renal, hepatic or endocrine dysfunction (hyperaldosteronism)
Decreased circulating volume decreases renal perfusion pressure and activates
the reninangiotensin-aldosterone system, which further increases sodium retention and maintains the edema.
Edematous disease states include
1. congestive heart failure (↑ hydrostatic pressure),
2. liver disease (↓ oncotic pressure),
3. nephrotic syndrome (↓ oncotic pressure) and
4. pulmonary edema (↑ hydrostatic pressure).
How is diuretics help remove the edema?
1. Diuretics decrease plasma volume by “forcing” increased elimination of sodium and water in the urine.
2. This decreases hydrostatic pressure and increases oncotic pressure, which favors absorption of edematous fluid in the interstitial space back into the intravascular
space, correcting the edema.