Diuretics 4 Flashcards Preview

Pharm Unit 4 by Hans Kim > Diuretics 4 > Flashcards

Flashcards in Diuretics 4 Deck (13)
Loading flashcards...
1

what are the 2 names of the thiadiazides?

1. hydrochlorothiazide
2. dihydrochlorothiazide

2

what are the 2 names of the thiazide-like drugs?

1. indapamide
2. metolazone

3

what is the main clinical use of the thiazides?

to control HTN

4

what are the other clinical usage of the thiazides?

1. chronic edema due to cardiac insufficiency
2. idiopathic hypercalciuria
3. nephrogenic diabetes insipidus-lithium therapy

5

what are the side effects of thiazide diuretics?

1. hypokalemia-diabetes
2. hyponatremia
3. contraction alkalosis
4. hyperuricemia
5. increased BUN and serum creatinine
6. hypercalcemia

6

what are the 2 types of potassium sparing diuretics?

1. antagonist of mineralcorticoids (aldosterone dependent)
2. inhibitors of epithelial sodium channels (aldosterone independent)

7

what is the K+ sparing agent that is antagonist of mineralocorticoids?

spironolactone

8

what the names of the 2 inhibitors of epithelial sodium channels?

1. triamterene
2. amiloride

9

what is the main clinical use of K+ sparing diuretics?

combination with loop or thiazide diuretics to minimize potassium depletion while controlling HTN

10

what are the other clinical use of K+ sparing diuretics?

1. edema due to CHF, cirrhosis, and nephrotic syndrome
2. primary and secondary aldosteronism
3. idiopathic hypercalciuria
4. lithium induced polyuria

11

what are the side effects of K+ sparing diuretics?

1. hyperkalemia
2. gender-specific effects of androgen receptor antagonism by spironolactone

12

what factors determine the diuretic activity?

1. plasma conc
2. renal blood flow
3. GFR
4. Tubular secretion
5. Tubular fluid conc

13

K+ sparing diuretics is used for patients with renal dz such as

1. renal failure
2. nephrotic syndrome