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Pharm Unit 4 by Hans Kim > Angina 2 > Flashcards

Flashcards in Angina 2 Deck (10)
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why is dipyridamole used in limit?

b/c it vasodilates coronary arteries which can enhance exercise induced ischemia


what is cilostazol?

a quinolinone derivative that inhibits cellular phosphodiesterase


what is the mech of cilostazol?

increases cAMP and results in inhibition of platelet aggregation


why is lipid lowering agents important to use?

LDL reducing agents decrease the risk of adverse ischemic events in patients with established CAD


ACE is also known as

kinase II that is responsible for degrading bradykinin to inactive fragments


what are the roles of bradykinin?

1. bradykinin is a vasodilator
2. increases vascular permeability
3. bradykinin can also cause cough and play role in angiodedema
--> thus, ACE inhibitors increase bradykinin


all ACE inhibitors end with



what are the 4 major side effects of ACE inhibitors?

1. dry cough
2. hypotension
3. hyperkalemia (due to decreased aldosterone)
4. angioedema


why are beta-blockers useful?

1. prevent MI and sudden cardiac death as well as reducing angina and ischemia
2. bind to beta-adrenoreceptors blocking the binding of epinephrine and norepinephrine to these receptors
3. stimulation of beta 1 receptors in the heart cause an increase in contractility, heart rate and conduction through the AV node


what does beta 2 result in?

beta 2 receptors in vascular smooth muscle result in vasodilation