Angina 2 Flashcards Preview

Pharm Unit 4 by Hans Kim > Angina 2 > Flashcards

Flashcards in Angina 2 Deck (10)
Loading flashcards...
1

why is dipyridamole used in limit?

b/c it vasodilates coronary arteries which can enhance exercise induced ischemia

2

what is cilostazol?

a quinolinone derivative that inhibits cellular phosphodiesterase

3

what is the mech of cilostazol?

increases cAMP and results in inhibition of platelet aggregation

4

why is lipid lowering agents important to use?

LDL reducing agents decrease the risk of adverse ischemic events in patients with established CAD

5

ACE is also known as

kinase II that is responsible for degrading bradykinin to inactive fragments

6

what are the roles of bradykinin?

1. bradykinin is a vasodilator
2. increases vascular permeability
3. bradykinin can also cause cough and play role in angiodedema
--> thus, ACE inhibitors increase bradykinin

7

all ACE inhibitors end with

-pril

8

what are the 4 major side effects of ACE inhibitors?

1. dry cough
2. hypotension
3. hyperkalemia (due to decreased aldosterone)
4. angioedema

9

why are beta-blockers useful?

1. prevent MI and sudden cardiac death as well as reducing angina and ischemia
2. bind to beta-adrenoreceptors blocking the binding of epinephrine and norepinephrine to these receptors
3. stimulation of beta 1 receptors in the heart cause an increase in contractility, heart rate and conduction through the AV node

10

what does beta 2 result in?

beta 2 receptors in vascular smooth muscle result in vasodilation