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Flashcards in Endo Drugs Deck (56)
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1

MoA of Calcitonin

Calcitonin lowers blood calcium and phosphorus mainly through its inhibition of osteoclasts.

2

Side effects of Testosterone

Prostatism
Polycythaemia
Hepatitis

3

Name some Dopamine agonists

Bromocriptine
Quinagolide
Cabergoline

4

Name some Somatostatin Analogues

Ocreotide

5

Name some GH antagonists

Pegvisomant

6

What is Levothyroxine

a manufactured form of the thyroid hormone, thyroxine (T4)

7

Name some anti-thyroid drugs

Carbimazole
Propylthiouracil

8

MoA of anti-thyroid drugs

inhibits the enzyme thyroperoxidase, which normally acts in thyroid hormone synthesis

9

MoA of Calcitonin (salmon)

It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).

10

Name a calcimimetic

Cinacalcet

11

MoA of calcimimetics

it mimics the action of calcium on tissues

12

What is cholecalcifol

Vitamin D3

13

MoA of Denosumab

inhibits this maturation of osteoclasts by binding to and inhibiting RANKL. This protects bone from degradation, and helps to counter the progression of the disease.

14

What is Teriparatide

is identical to a portion of human parathyroid hormone (PTH)

15

MoA of Teriparatide

use activates osteoblasts more than osteoclasts, which leads to an overall increase in bone

16

Name a Biguanide

Metformin

17

MoA of Metformin

- insulin sensitiser
- lowers gluconeogenesis
- increases glucose uptake in skeletal muscle
- decreases carbohydrate absorption
- increases fatty acid oxidation

18

Side effects of Metformin

Gi upset
Bad for liver
Lactic acidosis
reduces eGFR (reduce dose if <30-45, stop if <30 or if creatine >150)

19

Name some sulphonylureas

Short acting: gliclazide, glipizide
Long acting: glibenclamide, chlorpropramide

Others: Tolbutamide,

20

MoA of Sulphonylureas

- make beta cella release more insulin by blocking KATP chennels

21

Side effects of Sulphonylureas

- weight gain
- bad for liver/kideneys
- can cause hypo

Make sure to check blood glucose and LFTs

22

Name a Thiazolidinediones (TZDs/ Glitazones)

Pioglitazone

23

MoA of Thiazolidinediones

- activate PPARs (peroxisome proliferator-activated receptors) that then increase peripheral glucose uptake
- inhance action of insulin
- decrease hepatoglucose output

24

Side effects of TZDs

Weight gain
Hepatotoxic
Water retention (don't use in Heart failure)
Increased fracture risk

25

Name some Glucagon-like-peptide-1 agonsits (Incretin analogues/ GLP-1 agonists)

Exenatide, Liraglutide, Lixisenatide

26

MoA of Glucagon-like-peptide-1 agonsits

- increase insulin secretion
- early satiety (decreased gastric empting)
- reduces appetite through hypothalamic action

27

Side effects of Glucagon-like-peptide-1 agonsits

Pancreatitis / Pancreatic cancer

28

Name some Dipeptide peptidase 4 inhibitors (DPP-IV inhibitors)

Sitagliptin
Saxagliptin
Vildagliptin
Linagliptin
Agogliptin

29

MoA of Glucagon-like-peptide-1 agonsits

- stop the breakdown of GLP-1 by DPP-IV enzyme
- supressing glucagon
- increasing insulin secretion

30

Side effects of Glucagon-like-peptide-1 agonsits

Pancreatitis / Pancreatic cancer