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Flashcards in Cardio Drugs Deck (73)
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1

Give examples of ACE Inhibitors (ACE Is)

"pril"

Ramipril, Lisinopril and Quinapril

2

MoA of ACE Is

Inhibit ACE from converting angiotensin I into angiotensin II (a vasocontrictor)

3

Effect of ACE Is

Vasodilate, causing a reduce in blood pressure

4

Give examples of Angiotensin Receptor Blockers (ARBs)

"sartan"

Valsartan, Losartan and Eprosartan

5

MoA of ARBs

They are antagonists to angiotensin II (a vasoconstrictor)

6

Effect of ARBs

Vasodilate, causing a reduce in blood pressure

7

Give examples of Beta 1 Blockers (BBs)

"olol"

Atenolol, Bisoprolol, Metropolol

8

Give examples of Nonselective Beta Blockers (BBs)

"olol"

Propanolol

9

MoA of B1Bs

They block B1 adrenoceptors

10

Effect of B1Bs

- Decrease the force of contraction of the heart
- Decrease the HR

11

MoA of Nonselective BBs

They block both B1 and B2 adrenoceptors

12

Effect of Nonselective BBs

Basically blocks sympathetic responses:

- Decreases the HR (reduced SA-AV node conduction)
- Decreases force of contraction of the heart
- Have an antiarrhythmic effect
- Reduce Renin, so decrease BP

13

Give examples of Calcium Channel Blockers (CCBs)

Smooth Muscle selective: "dipines"

Amlodipine, Nifedipine and Felodipine

Cardio selective: Verapamil

Others: Diltiazem

14

MoA of CCBs

Block L-type Ca2+ channels in Smooth muscle

15

Effect of CBBs

- Vasodilation (Coronary and peripheral), so reduces BP
- Reduces myocardial oxygen consumption rate

16

Give examples of Anti-Arrhythmic drugs?

Digoxin, Adenosine, Amiodarone, Verapamil, Magnesium Sulphate

17

MoA of Digoxin

Blocks Na+/K+ pump, slowing AV node conduction

18

MoA of Verapamil

Blocks L-type Ca2+ channels, slowing AV node conduction

19

MoA of Adenosine

Stimulates adenosine receptor that inhibits adenyl cyclase, therefore inhibiting Ca2+ influx.

It hyperpolarises the AV node, suppressing conduction.

20

MoA of Amiodarone

Slows conduction of the SA and AV nodes

21

Give examples of Alpha Blockers

"zosin"

Prazosin and Doxazosin

22

MoA of A1 Blockers

Block A1 receptors

23

Effects of A1 Blockers

Vasodilation

24

Give examples of Nitrates

Short acting: Glyceryl trinitrate (GTN)
Long acting: Isosorbide mononitrate

25

MoA of Nitrates

They metabolise to produce NO, increasing cGMP, activating kinase A causing relaxation.

Also keeps K+ channels open.

26

Effect of Nitrates

Vasodilation

27

MoA of Ivabradine

It inhibits the funny channel and therefore inhibits the pacemaker activity of the SA node

28

Effect of Ivabridine

Decreases the HR

29

Give examples of Diuretics

Thiazide: Bendroflumethiazide
Loop: Furosemide

Others: Spironolactone

30

MoA of Spironolactone

- It is a competitive inhibitor of aldosterone
- It targets the distal nephron