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Flashcards in Derm Drugs Deck (38)
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1

Reversible side effects of Glucocorticosteroids

- Immunosuppression
- Contact allergy
- Steroid rebound of pustular psoriasis
- Spread of infection due to immune suppression
- Steroid rosacea
- Small superficial dilated blood vessels (telangiectasia)
- Purpura rash
- Steroid folliculitis (pustules in follicles)
- Peri-oral dermatitis
- Tinea incognito
- Reduced effect due to long-term use

2

MoA of topical Corticosteroids

Vasoconstrictive
Anti-inflammatory
Antiproliferative

3

Name a mild topical steroid

Hydrocortisone 1%

4

Name a moderate topical steroid

Modrasone 0.05%
Clobetasone 0.05%
Butyrate 0.05%

5

Name a potent topical steroid

Mometasone 0.1%
Betamethasone 0.1%
Valerate 0.1%

6

Name a very potent topical steroid

Clobetasol 0.05%
Proprionate 0.05%

7

MoA of Calcineurin inhibitors

Immunosuppressors

They suppress lymphocyte activation

8

Side effect of Calcineurin inhibitors

Immunosuppression
Burning sensation on application
Risk of infections
Risk of skin cancer

9

Name some Calcineurin inhibitors

Tacrolimus
Pimecrolimus
Ciclosporin

10

MoA of Antiseptics

They have bacteriostatic or bacteriocidal effects

11

Name some Antiseptics

Povidone iodine (Betadine)
Chlorhexidine (Hibitane, Savlon)
Triclosan (Aquasept, Sterzac)
Hydrogen peroxide (Crystacide)
Potassium Permanganate

12

Name an Anti-yeast

Nystatin

13

Name some anti-pruritics

Menthol (Dermacool)
Capsaicin
Camphor
Phenol
Crotamiton (Eurax cream)

14

MoA of Keratinolytics

Softens Keratin

15

Name some Keratinolytics

Salicylic Acid ointment (2-20%)
Benzoyl peroxide (Topical: Acnecide)

16

Side effects of topical therapies

Burning or irritation
Staining
Contact allergic dermatitis
Local toxicity
Systemic toxicity

17

1 fingertip unit of topical steroids = ?

Covers 2 hands areas

18

Non-reversible side effects of Glucocorticosteroids

- Skin atrophy (thinning of skin)
- Stretch marks (striae atrophica)
- Glaucoma
- Cataracts
- Hirsutism

19

Name Anti-fungals

Clotrimazole
Terbinafine cream
Ketaconazole

20

Function and target of Dasatinib and Imatinib

Prevents cell growth
C-kit caused Melanoma

21

Function and target of Vemurafenib
Dabrafenib

Prevents cell growth
B-Raf caused Melanoma

22

Function and target of Trametinib

Prevent cell growth
MEK caused Melanoma

23

Function and target of Ipilimumab, Tremelimumab and Pembrolizumab

T cell activation to enable tumour cell killing
CTLA-4 and PD-1 on T cells

24

Effects of phototherapy

Anti-inflammatory
Immunosuppression
Antiproliferative
Apoptotic

25

Name some Vitamin D analogues

Calcitrol
Tacalcitrol

26

Name the MoA of Vitamin D analogues

Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body. Psoriasis is caused by your skin cells being produced too quickly. Analogues help to bring the rate at which these skin cells are produced back to normal.

27

MoA of Acitretin

It binds to nuclear receptors that regulate gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia, leading to the slowing of cell reproduction.

28

Name some 2nd generation retinoids

Acitretin

29

Name some 3rd generation retinoids

Tazarotene
Adapalene (topical)

30

MoA of retinoids:

Dry out the skin

Retinoids have many important functions throughout the body including roles in vision,[1] regulation of cell proliferation and differentiation, growth of bone tissue, immune function, and activation of tumour suppressor genes.