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Flashcards in Child Health Drugs Deck (15)
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1
Q

What is the function of Orlistat

A

Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake.

2
Q

Whats the MoA of Orlistat

A

Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and instead are excreted unchanged. Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the GI tract after an oral dose. The primary route of elimination is through the feces.

3
Q

Name a Lipase Inhibitor

A

Orlistat

4
Q

Name side effects of Orlistat

A

GI problems (steatorrhea etc)

5
Q

Name contraindications for Orlistat

A

Pregnancy / breastfeeding

6
Q

Name some Nucleoside analog reverse-transcriptase inhibitors (NRTIs)

A

Abacavir and lamivudine

7
Q

What is the MoA of NRTIs

A

They inhibit viral replication

8
Q

Name a Non-nucleoside reverse transcriptase inhibitor (NNRTI)

A

efavirenz

9
Q

MoA of efavirenz

A

works by blocking the function of reverse transcriptase

10
Q

Name types of antiretrovirals

A

NRTIs, NNRTIs and protease inhibitors

11
Q

Name some protease inhibitors

A

Lopinavir and ritonavir

12
Q

The combination of Lopinavir and ritonavir is known as

A

HAART (Highly active antiretroviral therapy)

13
Q

MoA of protease inhibitors

A

Inhibit a particular liver enzyme that normally metabolizes protease inhibitors

14
Q

MoA of Artemisinin-based combination therapy

A

Works by attacking multiple parasite proteins

15
Q

MoA of Artesunate

A

It causes malarial protein damage