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Flashcards in GI Drugs Deck (43)
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1

Give examples of Antacids

Gaviscon

2

Side effects of Antacids

Nausea
Constipation
Diarrhoea
Headaches

3

MoA of Antacids

They contain alkaline ions that neutralise stomach acid

4

Effects of Antacids

Reduce acid reflux

5

Give examples of 5-Aminosalytic Acids

Mesalazine

6

Side effects of 5ASAs

GI upsets
Peripheral Neuropathy
Pancreatitis

7

MoA of 5ASAs

Release of aminosalicylic acid

8

Effect of 5ASAs

Reduce inflammation

9

Give examples of Anti-motility

Loperamide

10

Side effects of Anti-motility

Dizziness
Dry mouth
Vomiting
Constipation
Abdominal pain

11

MoA of Anti-motility

Stimulates opioid receptors

12

Effect of Anti-motility

Increases tone and contractions on the small intestine, constricts smooth muscle sphincters and inhibits peristalsis- causing constipation

13

Give examples of Anti-emetics

D1 receptor antagonists:
- Metoclopramide
- Domperidone

H1 receptors antagonists:
- Cyclizine:

14

Side effects of Anti-emetics

Avoid if at risk of hepatic encephalopathy
Avoid if patient has prostatic hyperplasia

Dry mouth
Restlessness

15

Give examples of H2 Receptor Antagonists

Ranitidine

16

MoA of H2 Receptor Antagonists

Competitive inhibitor of Histamine receptors on parietal cells

17

Side effects of H2 Receptor Antagonists

Nausea
Constipation
Diarrhoea
Headaches

18

Effects of H2 Receptor Antagonists

Decreases the production of stomach acid

19

Give examples of Immunosuppressants

Azathioprine and Methotrexate

20

MoA of Azathioprine and Methotrexate

Metabolites halt DNA replication of T and B cells

21

Side effects of Azathioprine

Pancreatitis
Leucopaenia
Hepatitis
Small risk of lymphoma, skin cancer

22

Effects of Azathioprine and Methotrexate

Immunosuppresses

23

Side effects of Methotrexate

Hepatotoxicity
Don't give in pregnancy as it's a chemo agent
Decreases WBC

24

Give examples of Proton Pump Inhibitors

Omeprazole
Bismuth Chelate

25

MoA of PPIs

Inhibition the H+/K+-ATPase system in parietal cells

26

Side effects of PPIs

Nausea
Fatigue
Dizziness
Diarrhoea
Headache

27

Effects of PPIs

Suppresses stomach acid secretion

28

Give examples of Anti-TNF-alphas

Infliximab

29

MoA of Anti-TNF-alphas

-Acts against TNF-alpha as an antibody
- Promotes apoptosis of T cells

30

Side effects of Anti-TNF-alphas

- Reactivation of TB/ Hep
- Drug-induced lupus
- Serious infections