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Flashcards in Endocrine Deck (163)
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1

which adrenergic receptors increase hepatic glucose output

beta 2 and 3

2

alpha 1 receptor works by which second messanger

IP3, Ca (Gq)

3

alpha 2 receptor works by which second messanger

Gi : decrease cAMP

4

beta1 receptor works by which second messanger

Gs increase cAMP

5

beta2 receptor works by which second messanger

Gs increase cAMP

6

alpha 1 prefers which adrenergic ligand

NE

7

alpha 2 prefers which adrenergic ligand

NE

8

which adrenergic receptor inhibits insulin release

alpha 2

9

beta 1 prefers which adrenergic ligand

NE=E

10

beta 2 prefers which adrenergic ligand

E

11

beta 3 prefers which adrenergic ligand

NE

12

where do you find beta 2 receptors

GI, urinary, adipose, liver, skeletal muscle, alpha cells in pancreas, bronchiole

13

where do you find beta 1 receptors

heart

14

where do you find alpha receptors

veins, lymph, beta cells in pancreas

15

beta3 receptor works by which second messanger

Gs increase cAMP

16

disease: high circulating catecholamines causing headache, palpitations, HTN, sweat, tachycardia

pheochromocytoma

17

disease: high cortisol, low ACTH

cushing syndrome (spontaneous or drug induced cortisol excess)

18

disease: high cortisol, high ACTH

cushing disease (pituitary adenoma)

19

how to distinguish cushing disease from syndrome

dexamethasone suppression test

20

osteoporosis, poor wound healing, virilization, HTN, round face, buffalo torso

cushing

21

treatment for cushings

ketoconozole, metyrapone

22

why do we get HTN with high cholesterol

alpha 1 stimulation causes vasoconstriction

23

disease: hypoglycemia, hypotension, hyperkalemia, acidosis, decreased hair and libido, hyperpigmentation

addisons

24

what will cortisol, CRH, ACTH look like in secondary adrenocortical insufficiency

low cortisol, high CRH, low ACTH

25

disease: primary adrenocortical insufficiency

addisons

26

why do we get hyper pigmentation with addisons

increased ACTH with alphaMSH can't stimulate adrenal cortex (cuz its messed up) but the MSH produces discoloration

27

disease: primary hyperaldosteronism

conn syndrome

28

disease: hypervolemic, hypernatremic, HTN, low K, low H (alkalosis)

Conn syndrome

29

how do you treat conn syndrome

spironolactone (aldosterone antagonist)

30

disease: overproduction of mineral corticoids can occur when we have deficiency in which enzyme

17alpha hydroxylase