Flashcards in HDM Midterm Deck (139)
Which type of immunity has no memory and responds the same way to every pathogen every time it infects? What are the main effector cells in this type of immunity?
Phagocytic cells, NK cells, Complement
Which type of immunity has memory and responds the faster upon subsequent infections? What are the main effector cells in this type of immunity?
B cells, T cells
Which type of immunity is considered the first line of defense?
Rapid, causes inflammation, low specificity, no memory: these are all descriptive of which line of immunity?
Develops slowly, high specificity, memory: these are all descriptive of which line of immunity?
What are the components of inflammation?
Hot, red, swollen, pain, loss of function
Describe what happens when bacteria invades skin surface causing inflammation.
Surface wound, bacteria enters, resident cells secrete cytokines, vasodilation, increased vascular permeability, inflammatory cells leave blood entering tissue, tissue becomes inflamed
Skin, mucous membrane, temperature, acidic pH, and lactic acid are all examples of which component of the innate immune system?
Which effector cell provides defense against helminths?
What do immune cells look For to distinguish between Self and non self?
pathogen associated molecular patterns (PAMPs) are recognized by pattern recognition receptors (PRRs)
What are examples of some bacterial PAMPs?
LPS, techoic acid, peptidoglycan, mannose proteins
Which toll-like receptor activates inflammation in the presence of Gram positive bacteria
TLR2- recognizes peptidoglycan
Which toll-like receptor activates inflammation in the presence of gram negative bacteria
TLR4- recognizes LPS
TLR1:TLR2 is a heterodimer cell receptor found on monocytes, mast cells, DCs, eosinophils and basophils that recognizes what kind of PAMP?
Lipopeptides on bacteria, GPI on parasites
TLR2:TLR6 is a heterodimer found on monocytes, DCs, mast cells, eosinophils, and basophils that recognizes what PAMPs?
Lipotechoic acid (gram + bact) and yeast
Which TLRs are found intracellular in the endosomes?
3, 7, 8, 9
TLR3 on NK cells detects what kind of PAMP?
Double stranded viral RNA
TLR4 on macrophage, DC, mast cells, and eosinophils that detects what PAMPs?
LPS on gram - bacteria
TLR5 on intestinal epithelium recognize what PAMPs?
TLR7 on DCs, NK cells, eosinophils, B cells recognizes what PAMPs?
Single stranded viral RNA
TLR8 found on NK cells recognizes what kind of PAMPs?
Single stranded viral RNA
TLR9 on DCs, B cells, eosinophils, and basophils recognize what kind of PAMPs?
Unmethylated CpG-rich DNA
Which TLRs recognize Bacterial lipopeptides?
Which TLRs recognize bacterial flagellin
Which TLRs recognize LPS
Which TLRs recognize peptidoglycan
Which TLRs recognize lipopeptides
Which TLRs recognize dsRNA
Which TLRs recognize ssRNA