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Flashcards in HDM Midterm Deck (139)
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1

Which type of immunity has no memory and responds the same way to every pathogen every time it infects? What are the main effector cells in this type of immunity?

Innate (natural)
Phagocytic cells, NK cells, Complement

2

Which type of immunity has memory and responds the faster upon subsequent infections? What are the main effector cells in this type of immunity?

Acquired (adaptive)
B cells, T cells

3

Which type of immunity is considered the first line of defense?

Innate

4

Rapid, causes inflammation, low specificity, no memory: these are all descriptive of which line of immunity?

Innate

5

Develops slowly, high specificity, memory: these are all descriptive of which line of immunity?

Adaptive

6

What are the components of inflammation?

Hot, red, swollen, pain, loss of function

7

Describe what happens when bacteria invades skin surface causing inflammation.

Surface wound, bacteria enters, resident cells secrete cytokines, vasodilation, increased vascular permeability, inflammatory cells leave blood entering tissue, tissue becomes inflamed

8

Skin, mucous membrane, temperature, acidic pH, and lactic acid are all examples of which component of the innate immune system?

Physical barriers

9

Which effector cell provides defense against helminths?

Eosinophil

10

What do immune cells look For to distinguish between Self and non self?

pathogen associated molecular patterns (PAMPs) are recognized by pattern recognition receptors (PRRs)

11

What are examples of some bacterial PAMPs?

LPS, techoic acid, peptidoglycan, mannose proteins

12

Which toll-like receptor activates inflammation in the presence of Gram positive bacteria

TLR2- recognizes peptidoglycan

13

Which toll-like receptor activates inflammation in the presence of gram negative bacteria

TLR4- recognizes LPS

14

TLR1:TLR2 is a heterodimer cell receptor found on monocytes, mast cells, DCs, eosinophils and basophils that recognizes what kind of PAMP?

Lipopeptides on bacteria, GPI on parasites

15

TLR2:TLR6 is a heterodimer found on monocytes, DCs, mast cells, eosinophils, and basophils that recognizes what PAMPs?

Lipotechoic acid (gram + bact) and yeast

16

Which TLRs are found intracellular in the endosomes?

3, 7, 8, 9

17

TLR3 on NK cells detects what kind of PAMP?

Double stranded viral RNA

18

TLR4 on macrophage, DC, mast cells, and eosinophils that detects what PAMPs?

LPS on gram - bacteria

19

TLR5 on intestinal epithelium recognize what PAMPs?

Flagellin (bacterial)

20

TLR7 on DCs, NK cells, eosinophils, B cells recognizes what PAMPs?

Single stranded viral RNA

21

TLR8 found on NK cells recognizes what kind of PAMPs?

Single stranded viral RNA

22

TLR9 on DCs, B cells, eosinophils, and basophils recognize what kind of PAMPs?

Unmethylated CpG-rich DNA

23

Which TLRs recognize Bacterial lipopeptides?

2, 6

24

Which TLRs recognize bacterial flagellin

5

25

Which TLRs recognize LPS

4

26

Which TLRs recognize peptidoglycan

2

27

Which TLRs recognize lipopeptides

1, 2

28

Which TLRs recognize dsRNA

3

29

Which TLRs recognize ssRNA

7, 8

30

Which TLRs recognize CpG DNA

9