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Flashcards in Enterics and review stuff Deck (30):
1

Enterobacteriaceae family

Gram negative bacilli, gut loving. Usually aerobic. Lots of them (don’t memorize)

2

Coliforms

ferment lactose, groups: Enterobacter, escherischia, klebsiella

3

Non-coliforms

non lactose fermenting. Sometimes normal (sometimes not): morganella, edwardsiella, proteus

4

Pathogenic non coliforms

Never good to find. Salmonella, shigella, yersinia

5

Culturing enterics

McKonkie Agar that differentiates b/w lactose fermentors and non

6

E coli and names

O (LPS antigen) and H (flagella antigen), ex. E coli O157:H7. The is K too for capsular (less common)

7

Klebsiella pathogenesis to cuase UTI

escape from gut into urinary tract, adhere via pili, avoid phagocytosis, cause tissue damage, get into bloodstream

8

Aspiration pneumonia and enterics?

Typically in large bowel, but in alcoholics they move up to the stomach, can get into lungs

9

Tx for UTI

TMXSMX, 1st gen cephalosporin, penicillins (increasing resistance to these)

10

HENPEK

H influenzae, enteric gram negs, neisseria, proteus, e coli, klebsiella

11

Tx for enteric gram neg

Ciprofloxacin, TMP SMX, aminoglycosides, carbapenems

12

Capsule bacteria

Neisseria, H influenza, S pneumonia

13

Bacteriocidal drugs would be used most for…

bloodborne infections that are serious.

14

Granuloma formation

Activated macrophages unsuccessful; T cell response recruits TH1, TNFa release, T cells and macrophages wall off area.

15

3 airborne diseases

TB, measles, chickenpox

16

Eosinophilia

Parasites, allergies, connective issues, cancer

17

Measles rundown

Resp droplet and airborne, replication in lymph nodes, viremia, activates cell mediated immunity - Infected endothelial cells = Koplick’s spots; infected epithelial cells = rash (low Vit A or low T cell = no rash, but can cause pneumonia and death)

18

Measles and Rubella - rash progression

Measles: Like dumping paint on your head. Starts at head, come together, then moves down. Rubella: starts in trunk and face, then to peripheries

19

B-19 review

Slapped cheek look. Can infect RBC and cause aplastic crisis… In adults causes lacey rash

20

What causes fever, then feel better, than rash?

HSV 6,7. Variola??

21

Vesicular rash

VZV and Coxsackie

22

VZV

Chicken pox/shingles

23

Coxsackie virus

Hand foot and mouth blisters

24

Tineas

Like keratin/lipids. Always on surfaces. Tx: topical agents.

25

RSV common presentation

common in young children, barking cough

26

Pathogenesis of H influenzae

Droplet or contact; adhesion via pili or LOS, local replication in nasopharynx; Yes capsule: invade bloodstream, can seed distantly and resists phagocytosis; No capsule: spread on mucous, middle ear, sinus, LRT; Both: LOS causes inflammation and tissue necrosis

27

Top drugs to cover S aureus

Cloxacillin or ampicillin+clavulanate; vancomycin for MRSA

28

Top drugs to cover S pyogenes

PENICILLIN; Amoxicillin; Pen + clinda (for nec fasc/toxic shock)

29

Bat bite

Clean the wound, rabies vaccine, rabies Ig

30

What causes grey teeth?

Tetracycline! Don’t use in pregnancy or young kids