Enzymes as drug targets

Question 1

What’s the function of a receptor?

Answer 1

To receive extracellular signals and initiate cellular responses

Question 2

Explain the role of an agonist

Answer 2

Activates receptors (full or partial)

Question 3

Explain the role of an antagonist?

Answer 3

Blocks receptor without activation can be competitive or non-competitive

Question 4

What’s the structure of a cell membrane

Answer 4

Lipid bilayer with embedded proteins

Question 5

What’s the function of the cell membrane ?

Answer 5

A selective barrier that regulates transport and signal tranduction

Question 6

What are the 2 different types of proteins that are in a cell membrane ?

Answer 6

Integral and Peripheral

Question 7

What are the 6 drug targets?

Answer 7

Enzymes
receptors
ion channels
nucleic acids
Transporters
Lipid bilayers

Question 8

What’s the mechanism for enzyme inhibition ?

Answer 8

Inhibitors mimic the substrate and bind to the active site reducing enzymatic activity

Question 9

What are the 5 types of inhibition

Answer 9

reversible
Competitive
Non-competitive
Uncompetitive
irreversible

Question 10

Explain what happens during reversible inhibition

Answer 10

Can dissociate from the enzyme

Question 11

Explain what happens during competitive inhibition?

Answer 11

Binds to the active site and competes with the substrate

Question 12

Explain what happens during Non-competitive inhibition

Answer 12

Binds elsewhere changing the enzyme shape

Question 13

Explain what happens during uncompetitive inhibition

Answer 13

Binds only to ES complex

Question 14

Explain what happens during irreversible inhibition?

Answer 14

Covalent/permanent modification of the enzyme

Question 15

define antibiotics

Answer 15

Medications that slow down or destroy growth of bacteria

Question 16

True or false : Antibiotics can treat viral infections?

Answer 16

False

Question 17

What are the 2 ranges of bacteria