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Flashcards in Erectile Dysfunction (ED) Deck (10):
1

Revatio
Viagra

- MOA
- C/I
- ADEs
- Dose/Indication
- DDI

Sildenafil

- MOA: PDE5 inhibitors => inc cGMP => incr SM relaxation and inflow of blood into the corpus cavernous.
- C/I: nitrate use (severe hypoTN)
- ADEs: HA, flushing, visual disturbances, insomnia, diarrhea

Dose/Indication
- ED (Viagra): 25-100 mg PO 1H prior to intercourse
- Pulm HTN (Revatio): 20 mg PO TID

DDI
- Caution w/ alpha blockers
- CYP3A4 substrate

2

Adcirca
Cialis

- MOA
- Indication/Dose
- DDI

Tadalafil

- MOA/SEs: similar to sildenafil

Indication/Dose
- ED: 10mg 30min prior to intercourse. Work up to 36H
- BPH: 5mg PO QD
- Pulm HTN: 40mg PO QD

DDI:
- Avoid nitrate. Give 48H after last dose
- Caution with alpha-blocker: hypoTN
- 3A4 substrate

3

Levitra

- MOA/SEs
- Indication
- Dose
- DDI
- Other SEs

Vardenafil

- MOA/SEs: similar to viagra
- Indication: ED
- Dose: 10mg 1H prior to intercourse

DDI
- Ritonavir
- Alpha-blocker
- CI with nitrates for 72H

Other SEs
- Sudden hearing loss
- Sz

4

Stendra

- MOA/SEs
- Dose
- DDI

Avanafil

- MOA/SEs: similar viagra
- Dose: 50-200mg ~30 prior to intercourse

DDI:
- CYP3A4 inhibitor
- Alpha blocker

5

MUSE

- MOA
- How to administer
- Storage

Alprostadil

- MOA: widening blood vessels, inc blood flow to the penis and help cause an erection

- MUSE = transurthral therapy. Small pellet that is inserted into the urethra with an applicator. When press the button on the applicator, u release the pellet. It absorbed and an erection develops in ~10 min and last ~30min. Do not use more than 2x in 24H.
- Store in fridge

6

Staxyn

- Form

Vardenafil

- Form: ODT 10mg

7

Caverject

Alprostadil

- Caverject: Inject into the spongy tissue to the penus (corpus cavernosum). Not to be used more than 3x/wk.

8

Caverject impulse

- Storage

Alprostadil

- Store: unreconstituted at RT

9

Caverject sterile powder

- Storage

Alprostadil

- Store: fridge

10

Caverject solution

- Storage

Alprostadil

- Store in FREEZER