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Flashcards in Multiple Sclerosis Deck (10):
1

MS is an autoimmune disease in which the body's immune system attacks the CNS. It affects the ability of nerve cells in the brain and spinal cord to communicate with each other by attacks myelin sheath

- Manage acute attack

Acute attack
- Corticosteroid to reduce inflammation
IV methylprednisone with catheter insert in the arm and left it there for 3-5 days. Then pt will be taper with prednisone.

2

Ampyra

- Indication
- Dose
- SEs
- Available through specialty pharmacy.

Dalfampridine

- Indication: relapsing MS
- Dose: 10mg PO BID
- SEs: SZ
- Available through specialty phram

3

Gilenya

- Indication
- MOA
- Dose
- SE/Serious SEs

Fingolmod

- Indication: relapsing MS
- MOA: a sphingosine 1-phosphate receptor modulator
- Dose: 0.5mg PO QD
Should observe x 6H of 1st dose for s/s of bradycardia

SEs
- HA, flu, diarrhea, back pain, abn LTF, cough

Serious SEs
- Bradycardia
- Infection
- Vision/Breathing/Liver problem

4

Capaxone

- Indication
- Dose

Glatiramer

- Indication: MS
- Dose: 20mg SC QD

5

Avonex

- Indication
- Dose
Avonex


- Interferon monitoring
- Interferon SEs

Interferone Beta 1A

- Indication: MS

- Dose: Avonex: 30mg IM QW
- Prefilled syringe. Refrigerate. RT x 7d. Protect from light
- Vials: refrigerate. RM x 30d. Protect from light

Interferone monitoring
- CBC w/ diff
- Depression/suicidal
- Thyroid
- S/S of CV
- LFTs (Rebif)
- Seizures

Interferon SEs
- Flu like sx: fever, night sweats, muscle ache

6

Betaseron
Extavia

- Dose
- Storage

Interferone Beta 1B

- Dose: SC QOD
- RT until reconstitute, then refrigerate and use w/in 3Hs

7

Tysabri

- Indication
- MOA
- SE
- Special program

Natalizumab

- Indication: MS and Crohn's Disease
- MOA: monoclonal antibody
- SEs: serious brain infection
- Program: Pts, prescribers and pharmacies must be enrolled in the Tysabri Outreach Unified Commitment to Health (TOUCH).

8

Rebif

Interferone beta 1A

- F: SC 3x/W
- Refrigerate. RT x 30d. Protect from light

9

Techfidera

- Form
- Indication

Dimethyl fumarate

- F: PO
- I: Relapse MS

10

Lemtrada

- Form
- Indication

Alemtuzumab

- F: IV
- I: Relapse MS