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Flashcards in HIV - Brand/Generic Deck (54):
1

Protease Inhibitors
- MOA
- Take w/:
- Excrete:
- Sulfa allergy

- Protease enzyme breaks down the protein into function units to be used for final assembly of new virus. Protease inhibitors inhibit this enzyme

- All take w/ food except Indinavir and Fosamprenavir suspension
- All excrete the LIVER
- Sulfa allergy: fosamprenavir, darunavir, tiprinavir

2

AgenerASE

AMprenavir

=> Cha Am dan dan bi erASE ddi

3

CRIXivan

- SE

INDInavir

- Kidney stone (Nephrolithiasis) => take w/ plenty of wate

4

Kaletra

Storage
- Suspensions
- Cap

Lopinavir-Ritonavir

- Susp Sol'n => take w/ FOOD; REFRIGERATION b/c it contains EtOH
- Film coated capsule: do not refrigerate

5

Viracept

Nelfinavir

- Bad diarrhea

6

NORvir

- Storage
- SEs

RITonavir

Storage:
- Cap: refrigerate
- Tab/Sol: RT

SE
- Has bad GI, paresthesias

7

Invirase

SaQUINavir

8

Aptivus

- SEs
- BBW

TIPranavir

- Has EtOH

SE
- Fatal hepatotoxicity
- Sulfa allergy

BBW: intracranial hemorrhage

9

Lexiva

FoSAMprenavir

- Sulfa allergy
- Suspension take on empty stomach

10

ReyaTAZ

- SEs

ATAZanavir

- Doesn't increase lipid
- Take QD

SEs
- Cardiac abnormalities
- Most DDI

11

Prezista

- SEs
- Direction to take

DaRUNavir

- Sulfa allergy
- Take BID with FOODs and ritonavir

12

Nucleoside Reverse Transcriptase Inhibitors (NRTI's)

- SE

- Inhibits reverse transcriptase from convert RNA to DNA (Proviral DNA)

- Lactic acidosis

13

Zerit

STAvudine

- SEs:
GI intolerance
Pancreatitis
Peripheral neuropathy
Lactic acidosis
Lipodystrophy

14

EPivir

LAMivudine

15

Retrovir

ZiDOvudine

16

Videx

- Direction to take
- SEs

DiDANosine

- Take on empty stomach
- SEs: Pancreatitis, peripheral neuropathy, retinal pigmentation, and lactic acidosis

17

Ziagen

Abacavir

- SEs: Hypersensitivity rx HLA B*5701. D/c and do not re-challenge

18

Viread

- SEs

Tenofovir

- SEs: lactic acidosis, hepatotoxicity.
Acute renal failure/Fanconi syndrome
Osteoporosis

19

EMTRIva

EMTRIcitabine

20

Integrase inhibitors
- MOA

- Inhibit HIV DNA integrate into host cell DNA

21

Insentress

- MOA

Raltegravir

- MOA: Inhibit HIV DNA integrate into host cell DNA

22

Tivicay

- MOA
- Age
- SEs

Dolutegravir

- MOA: Inhibit HIV DNA integrate into host cell DNA
- Age: for pt > 12 y.o
- SEs: HA, insomnia

23

Entry Inhibitors
- MOA

- Inhibit HIV binding and fusion therefore HIV can't get inside celly

24

Fuzeon

- MOA
- SEs

Enfuvirtide

- MOA: Target the gp120 or gp41 proteins on HIV's surface
- SE: may cause infection

25

Selzentry

- MOA
- Rec dose
* Take with inhibitors
* No inhibitors/inducers
* Take with inducers
- SEs

MAraviroc

- Is CCR5 (Chemokine receptor type 5) blocker & antagonist
- CCR5: is a protein which HIV uses to enter its target cells

** Rec initial dose is 150mg BID if also on inhibitors
** Rec dose is 300mg BID
** Rec initial dose 600mg BID if also on inducers

- SE: hepatotoxicity, heart problem, orthostatic hypoTN

26

Non- Nucleoside Reverse Transcriptase Inhibitors (NNRTI's)
- MOA

- Inhibits reverse transcriptase from convert RNA to DNA (Proviral DNA)

27

Viramune

NeVIRApine - ne VYE ra peen

28

Intelence

- SEs

ETRAvirine - et tra VIR reen

- SEs: severe skin RASH

29

Rescriptor

- SEs

Delavirdine

- SE
Rash, hepatotoxicity (least)

30

SUstiva

- SEs
- Preg Cat
- Direction to take:

EFAvirenz

- SEs: CNS sx: vivid dream, hallucination, false cannabinoid test
- Preg Cat D
- Take on empty stomach

31

Eduran

- SEs

Rilpivirine - Ril pi VIR reen

- SEs: depression, insomnia

32

Glycoproteins gp41
- Function

- Helps to initiate the process of membrane fusion b/w virus and cell

33

Combivir

=> Come LZ

Zidovudine + Lamivudine

34

EPizicom

=> EP co Lam

Abacavir + Lamivudine

35

TriZivir

LAZ = Trinity last

Zidovudine + Lamivudine + Abavavir

36

Truvada
- Combo
- Indication

=> TE

- Tenofovir + Emtricitabine

Indication
- FDA approved for PREVENTION of HIV infection in adults 1 tab PO QD

37

Atripla

- Gold standard
- Never give to
- Take w/ ?

Efavirenz + Emtricitabine + Tenofovir

- Never give to preg woman
- Take QD on Empty stomach

38

CompleRa

- Take with

- Emtricitabine + Tenofovir + Rilpivirine
- Take with FOOD 1 tab QD

39

Stribild: (TEEC)

- Take w/
- CrCl

- Elvitegravir + cobicistat + emtricitabine + tenofovir disoproxil fumarate

- Take with FOOD 1 tab QD
- CrCl

40

Fxn of Cobicistat

- Enhancer to prolong the effect of Elvitegravir + emtricitabine + tenofovir

41

Vitravene

- How to give
- Indication

Fomivirsen

- A shot directly into the disease eye x 2 separate by 2W
- Approved for CMV who have failed other therapy

42

Rebetol, Copegus

- Indication
- SEs
- Preg Cat

Ribavirin

- Indication: Hepatitis C use in combo with interferon
- SEs/CI: Sig heart disease
- Preg Cat X

43

Pegylated Interferon

- Brand
- SEs

Pegasys; PEG-Intron

- Depression & suicidal behavior

44

Egrifta

- MOA
- Indication
- Dosage
- CI

Tesamorelin Injection

- MOA: growth hormone releasing factor analog

Indication
- Reduces excess abdominal fat in HIV-infected patients with lipodystrophy

Dosage:
- 2mg SC QD

CI
- Pregnant
- Active malignancies

45

Fulyzaq

- Indication

Crofelemer

- Indication: Anti-diarrha for symptomatic relief of non-infectious diarrhea in pts with AIDs/HIV on anti-retrovial therapy

46

Dapsone

- Indication

Sulfadiazine

- CMV ppx

47

Daraprim

- Indication
- MOA

Pyrimethamine

- Indication: antimalaria
- Use in combination with leucovorin + sulfadiazine for toxoplasmosis treatment
- MOA: inhibits parasitic dihydrofolate reductase

48

Foscarvir

Foscarnet

- CMV
- SEs: Nephrotoxic, seizure

49

Cytovene

- Direction to take it

Ganciclovir

- Take with FOOD

50

Vistide

Cidofovir

- CMV
- SE: severe nephrotoxicity = must taken with probenecid to help prevent kidney damage

51

Valcyte

Ganciclovir

- CMV

52

Vitrasert

Ganciclovir implants

53

Vitravence

Fomiversen

- Shot directly into the eye x 2 separate by 2wks

54

Triumeq

Abacavir + Lamiviudine + Dolutegravir