Exam 2 Flashcards
(181 cards)
The 3 phases/steps in carcinogenesis
- initiation- an event (often a carcinogenic agent) that causes the permanent genetic alteration that gives the cell neoplastic potential
- Promotion- an event that stimulates clonal proliferation of the initiated neoplastic cell*
- Progression- the process leading to malignant behavior (invasion and spread)
*reversible (step 3 can be reversible or irreversible)
abnormal swelling, a lesion that results in atonomous growth of a cell that persists after initiating stimulus has been removed
neoplasm= new growth
clinical side use
tumor
process of carcinogensis
a normal cell turning into neoplastic
transformation
“CA” ones that invade or metastasized
malignant
__% of CA risks is due to environmental agents (vs. inherited)
85%
how can you identify environmental risk factors of CA
- epidemiological studies
- occupational risks
- Direct accidental exposure
- Experimental testing
give examples of occupational risks associated with CA
- Scrotal CA in men who chimney sweeps (linked to polycyclic aromatic hydrocarbons
- Lung CA in people who smoke
- Cervical CA in sex-workers (linked to HPV)
give examples of direct accidental exposure that resulted in risks associated with CA
- “Radium Girls” → radiation resulted in bone CA
- Thorotrast use to be used as a contrast dye→ caused liver CA
- Radioactive iodine after nuclear explosion concentrated in thryroid→ resulted in thyroid CA in children
give examples of experimental testing that lead to risks associated w/ CA
- Test for mutagenicity in bacterial cultures
- Test for transforming capabilities in cell culture
- Monitor tumor incidence in lab animals
Ex. food additives, new drugs, potential environmental pollutants
Epideiologic evidence that certain kinds of tumors have a putative carcinogenic agent
- Heptaocellular Carcinoma- 2 factors involved include mycotoxins and hepatitis viruses B and C
- Esophageal CA- linked to something in the Linhsien’s food because they fed their scraps to their chickens and most developed esophageal CA even after moving locations
- Lung CA- cigarette smoke
- Cervical CA- HPV
- Bone CA- radiation
common examples of carcinogens
- chemicals
- Viruses
- Radiation
- Exogenous hormones (estrogen–> breast and endometrial CA)
- Bacteria
- Fungi and parasites
H. pylori is associated with what CA
gastric CA
aflatoxins is associated with what CA
liver CA
Chemical carcinogen: polycyclic aromatic hydrocarbons is associated w/ what CA
lung and skin CA
Chemical carcinogen: Aromati amines is associated w/ what CA
bladder CA
*In rubber and dye workers
Chemical carcinogen: Nitrosamines/nitrites is associated w/ what CA
gut CA
*Used in fertilizers and can get into water (Proven in animals)
Radiation carcinogen: UV light is associated w/ what CA
skin CA like melanoma
ionizing radiation is associated w/ what CA
- leukemia in some of the first radiology workers
- skin cancer for those whose hands regularly exposed to X-ray beams
- radiation in Hiroshima and Nagasaki following atomic bombs in 1945 increased tumor incidence in survivors
host factors that can affect ones risk of CA
- inherited genes (XP= skin CA, BRCA /2= breast and ovarian CA)
- Race (white= increased risk of skin CA)
- Gender
- Age
- Diet (high dietary fat increases risk of both breast and colon CA)
what viruses can cause CA
- HPV (16 and 18)
- Hep B and C
- EBV
- Human herpesvirus-8
- Human T-cell lymphotropic virus-1
HPV is associated w/ what CA
cervical CA
common wart- squamous cell papilloma
EBV is associated w/ what CA
Burkitt’s lymphoma
Nasopharyngeal CA
Hep B and C are associated w/ what CA
Hepatocellular carcioma
Human herpesvirus-8 is associated w/ what CA
Kaposi’s sarcoma
Pleural effusion lymphoma
*explains association btwn venerally acquired AIDS and Kaposi’s sarcoma