Exam 2: Chronic Inflammation

Question 1

What are the 4 outcomes of acute inflam?

Answer 1

1. complete resolution
2. Healing by scarring
3. Abscess formation
4. Progression to chronic inflam

Question 2

Involves neutralization of the chemical mediators, with subsequent return of normal vascular permeability, cessation of leucocyte infiltration and finally removal of edema, leucocytes, foreign agents, and necrotic debris

Answer 2

Resolution

Question 3

Type of inflam. resulting from injurious persisten stimuli, which leads to a predominantly proliferative, rather than, exudative rxn.

Answer 3

Chronic inflam

Question 4

in most cases ____ is the hallmark of fibrosis

Answer 4

Fibrosis

Question 5

What cell types are predominent in chronic inflam?

Answer 5

1. Macrophages
2. lymphocytes
3. plasma cells

Question 6

A specific type of chronic inflam characterized by accumulation of modified macrophages, epithelioid cells, and initiated by a variety of agents

Answer 6

Granulomatous inflam

Question 7

small, organized collections of modified macrophages called epithelioid macrophages, usually surrounded by a rim of lymphocytes

Answer 7

Granuloma

Question 8

stimuli resistant to phagocyte killing and degradation will result in _____ inflam.

Answer 8

Granulomatous

Question 9

What are the 3 cells involved inn Granulomatous inflam?

Answer 9

Epithelioid cells
Multinucleated giant cells
Lymphocytes

Question 10

______ are the sources of the multinucleated giant cells, which are believed to be formed by the coalescence of single macrophages

Answer 10

Macrophages

Question 11

What are epithelioid cells?

Answer 11

Specialized macrophages rich in the ER, Golgi, and vesicles, that are specialized for extracellular secretion

Question 12

multinucleated Giant cells are formed by coalescence and fusion of _____ cells

Answer 12

Epithelioid

Question 13

What are the roles of T- lymphocytes in granulomatous inflam

Answer 13

1. produce lymphokines and interferon
2. attract and activate macrophages
3. induce formation of multinucleated giant cells

Question 14

What are the 2 gross patterns of chronic inflammation

Answer 14

1. diffuse: thickening of affected tissue

2. solid, firm, nodular lesions which may compress adj. tissues

Question 15

What are the 2 types of granuloma

Answer 15

1. simple

2. complex

Question 16

Type of granuloma with organized accumulation of macrophages and epithelioid cells, often rimmed by lymphocytes

Answer 16

Simple granuloma

Question 17

Type of granuloma with a central area of necrosis

Answer 17

Complex granuloma