Flashcards in Exam 3-1 Deck (16)
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1
Golgi functions (4)
-synthesis of sphingolipids
-proteolytic processing
-post-translational modification of proteins and lipids
-sorting of proteins and lipids for post-golgi compartments
2
clathrin - moves from the
lysosome to the PM and back
3
COPI - moves from the
golgi to the ER
4
COPII - moves from the
ER to the golgi
5
N-linked glycosylation
carbohydrate complex added to an aspraganine in the ER lumen
6
multiple TM domains:
aa, CFTR and VGNa channels
12, 12, 24
7
Type I TMD, COO- in the _______ and NH3+ in the _______
cytoplasm, ER lumen
8
Type II TMD, COO- in the _______ and NH3+ in the _______
ER lumen, cytoplasm
9
BiP
-chaperon
-luminal face
-binds protein through translocon and helps it fold
10
SRP
signal recognition particle
11
Nup 358/RanBP2
acute necrotic encephaly
hetero missense T585M
12
Nup 62
primary biliary cirrhosis - autoimmune antigen & auto rec inflamm bilat striatal necrosis - homo miss Q391P
13
Nup 98
AML
fusion with Nup 98
FG repeats
14
Nup 155
AF
homozygous missense R391H
15
Cowden Syndrome
PTEN is translocated by KapB
no NSL --> no translocation into the nucleus
16
