Exam 3-1 Flashcards Preview

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Flashcards in Exam 3-1 Deck (16)
1

Golgi functions (4)

-synthesis of sphingolipids
-proteolytic processing
-post-translational modification of proteins and lipids
-sorting of proteins and lipids for post-golgi compartments

2

clathrin - moves from the

lysosome to the PM and back

3

COPI - moves from the

golgi to the ER

4

COPII - moves from the

ER to the golgi

5

N-linked glycosylation

carbohydrate complex added to an aspraganine in the ER lumen

6

multiple TM domains:
aa, CFTR and VGNa channels

12, 12, 24

7

Type I TMD, COO- in the _______ and NH3+ in the _______

cytoplasm, ER lumen

8

Type II TMD, COO- in the _______ and NH3+ in the _______

ER lumen, cytoplasm

9

BiP

-chaperon
-luminal face
-binds protein through translocon and helps it fold

10

SRP

signal recognition particle

11

Nup 358/RanBP2

acute necrotic encephaly
hetero missense T585M

12

Nup 62

primary biliary cirrhosis - autoimmune antigen & auto rec inflamm bilat striatal necrosis - homo miss Q391P

13

Nup 98

AML
fusion with Nup 98
FG repeats

14

Nup 155

AF
homozygous missense R391H

15

Cowden Syndrome

PTEN is translocated by KapB
no NSL --> no translocation into the nucleus

16

Male--> female sex reversal

importin B1 binds to SRY and translocates to nucleus
no NLS --> no translocation