Exam 3-16 Flashcards Preview

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Flashcards in Exam 3-16 Deck (8)
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1

CAMs

when bound to a ligand have a conformational change, form TM link

2

cadhedrin

single pass TM glycoprotein that operates as a homodimer, Ca2+ dependent

3

IgSF

single pass TM glycoprotein, homophobic binding, no dimers, no Ca2+

4

integrins

"classic" AMs, heterophilic, A/B heterodimer

5

CAMS linked to cytoskeleton and also regulate

adhesion, control actin polymerization, mediate cell signaling

6

in development, CAMs change as ___________

cells differentiate

7

ECM and disease

-collagen= osteogenesis and skeletal dysplasias
-lamin= nephrotic syndrome and neuromuscular junction/muscular problems in children
-MMP - LOF mutations 2 or 13 = osteolysis/arthritis/bone diseases

8

cell adhesion and disease

leukocyte adhesion
-type I - integrin, type 2 - selectin
cancer