Exam 3-4 Flashcards Preview

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Flashcards in Exam 3-4 Deck (13)
1

GADD45

inhibits cdc --> inhibits M phase entrance

2

P21

inhibits cdk 2 which inhibits entrance into the S phase and inhibits cdc2 which inhibits entrance into the M phase

3

LFS: hits may be

on different genes

4

DKA: Mannitol

raises blood osM

5

DKA tx: make sure youuuu

give dextrose + insulin long enough and slowly enough to bring glucose back into range

6

bicarb formula

H+ + HCO3- H2CO3 H2O + CO2

7

aldosterone function

increases Na concentration in DCT and cortical collecting duct of the kidney --> Na+ is retained and K+ is lost in the urine

8

Cushing's triad

- HTN
- bradycardia
- irreg respirations

9

insulin has____ aa and is in the ________

51
B cells of the pancreas

10

target site of insulin: liver

store glucose (as glycogen) and lipid, stop lipid and glycogen breakdown

11

target site of insulin: adipose tissue

store glucose and triglyceride (incorporated into chains of fats)

12

target site of insulin: muscle

store glucose, make protein

13

stimulus for insulin release

Glucose enters the beta cells in the pancreas --> increased ATP/ADP ratio --> closes a channel to cause rising intracellular potassium --> increasing intracellular potassium depolarizes the membrane --> Calcium ions influx --> leads to insulin exocytosis