Flashcards in Exam 3-5 Deck (15)
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1
n-sec1
refolds syntaxin into active formation
2
NSF and alpha-SNAP
disassemble protein
NSF uses ATP hydrolysis
3
VAMP location
transport vesicle
4
SNAP location
target membrane
5
syntaxin location
target membrane
6
HIF is a ____ that is _____ dependent.
TF
oxygen
7
HIF-alpha is ______ by ___ and ___
hydroxylated by proline and aspraganine
8
VHL _____ normal HIF-alpha
ubiq
9
use _______ to target downstream GFs of HIF and ______ to target mTOR
S-------nib
______lumin
10
VHL is a
tumor suppressor
11
sign of VHL
hemangioloastomas
12
Type 1, 2A and 2B ____regulate HIF
up
13
Type 2C ____regulates HIF
down
14
most VHL are
clear cell sporadid
15
