Exam 3-6 Flashcards Preview

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Flashcards in Exam 3-6 Deck (14)
1

HMGCoA is blocked by

statins

2

SREBP

reg LDLR and synthesis proteins

3

low cholesterol -->

SREBP TF releases

4

SREBP is held in the ___ and cleaved in the ______

ER, golgi

5

SCAP binds

SREBP and sterols

6

insig binds

SCAP and increased cholesterol

7

_______ carries SCAP to the golgi

COPII

8

RIP proteins

S1P and S2P (need both to activate)

9

cholesterol made of

polar OH group
steriod ring
hydrocarbon tail

10

sphingolipids made of

-ceramide
-polar head group

11

phospholipids made of

glycerol + 3P
polar head group
hydrocarbon tail

12

erbB2

HER2/neu oncogene
found in breast cancers
can be reversed by Herceptin

13

Gleevec

BRC-ABL
philadelphia chromosome
tyrosine kinase inhibitor

14

Estrogen receptor is a(n)

oncogene