Flashcards in Exam 3-10 Deck (13)
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1
Calnexin
TMP, binds oligosaccharide and Ca2+
2
calcreticulum
lumen protein, binds oligsaccharides and Ca 2+
3
retrotranslocated protein
deglycosylated, polyubiq
4
proteosome
central cyllinder cleaves, caps recognize polyubiq and uses ATP to unfold protein
5
ubiquinine ligase enzymes
E1 binds and activates, E2, E3 substrate specificty leads to polyubiq
6
lysosome lumen =
5 (due to H+ pump)
7
necrosis
pumps fail, cell swells and busts leading to inflammation
8
apoptosis
nucleus collapses, chromatin is super condenses and cell shrinks
9
LAMP2A
where proteins go to be degraded, highly regulated
10
autophagy has a __________ vehicle
double membrane
11
autophagy cancer tx
combination of drugs
12
protein is tagged with ______ and incripted into autophagosome membrane
lipids
13
