Exam 3-10 Flashcards by Lauren Oberle | Brainscape

Flashcards in Exam 3-10 Deck (13)

1

Calnexin

TMP, binds oligosaccharide and Ca2+

2

calcreticulum

lumen protein, binds oligsaccharides and Ca 2+

3

retrotranslocated protein

deglycosylated, polyubiq

4

proteosome

central cyllinder cleaves, caps recognize polyubiq and uses ATP to unfold protein

5

ubiquinine ligase enzymes

E1 binds and activates, E2, E3 substrate specificty leads to polyubiq

6

lysosome lumen =

5 (due to H+ pump)

7

necrosis

pumps fail, cell swells and busts leading to inflammation

8

apoptosis

nucleus collapses, chromatin is super condenses and cell shrinks

9

LAMP2A

where proteins go to be degraded, highly regulated

10

autophagy has a __________ vehicle

double membrane

11

autophagy cancer tx

combination of drugs

12

protein is tagged with ______ and incripted into autophagosome membrane

lipids

13

atg genes
(1, 12 and 6)

regulate autophagy
-1 = protein kinase
-12 = ubiq
-6 = Beclin1 = scaffold