Flashcards in Exam 3-2 Deck (14)
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1
Karyopherins
facilitate nuclear transport through the NPC as mediators
-B - receptors
-A - adapters (cargo selective binding)
2
nucleoporins
-building blocks of the NPC
-TF during development
-marker for cancer (244 and 88)
3
nucleoporin N-terminus
XFXFG (FG repeats)
4
nucleaporin C-terminus
heptad rep and coiled-coil conformation
5
anesthetics are on the _____ part of the VG Na channels and have a greater effect on the axons that are _____ and ______. ex: _______
-intracellular
-smaller
-more active (i.e. pain receptors)
-lidocaine
6
neurotoxins: extracellular blockers
-tetrodotoxin (puffer fish)
-saxitoxin (clams)
7
neurotoxins: modulators of Na+ channel function
batrochotoxin (frogs)
8
demyelinating diseases
MS (CNS) and Guillain-Barre syndrome (muscles)
9
current propagation: effect of increased internal resistance
smaller spread
10
current propagation: effect of increased membrane resistance
larger spread
11
current propagation: effect of increased membrane capacitance
slower speed
12
how to make the current propagation large and fast?
increase membrane resistance and decrease membrane capacitance
13
myelin's effect on current propagation
-increases membrane resistance and decreases membrane capacitance
-saltatory conduction
-faster and larger
14
