Exam 3-2 Flashcards Preview

M2M Unit III > Exam 3-2 > Flashcards

Flashcards in Exam 3-2 Deck (14)
1

Karyopherins

facilitate nuclear transport through the NPC as mediators
-B - receptors
-A - adapters (cargo selective binding)

2

nucleoporins

-building blocks of the NPC
-TF during development
-marker for cancer (244 and 88)

3

nucleoporin N-terminus

XFXFG (FG repeats)

4

nucleaporin C-terminus

heptad rep and coiled-coil conformation

5

anesthetics are on the _____ part of the VG Na channels and have a greater effect on the axons that are _____ and ______. ex: _______

-intracellular
-smaller
-more active (i.e. pain receptors)
-lidocaine

6

neurotoxins: extracellular blockers

-tetrodotoxin (puffer fish)
-saxitoxin (clams)

7

neurotoxins: modulators of Na+ channel function

batrochotoxin (frogs)

8

demyelinating diseases

MS (CNS) and Guillain-Barre syndrome (muscles)

9

current propagation: effect of increased internal resistance

smaller spread

10

current propagation: effect of increased membrane resistance

larger spread

11

current propagation: effect of increased membrane capacitance

slower speed

12

how to make the current propagation large and fast?

increase membrane resistance and decrease membrane capacitance

13

myelin's effect on current propagation

-increases membrane resistance and decreases membrane capacitance
-saltatory conduction
-faster and larger

14

fastest to slowest reception (myelinated)

1. propioreception
2. touch reception
3. temerature/pain