Exam 3: Autoimmune diseases Flashcards Preview

Pharmacology II > Exam 3: Autoimmune diseases > Flashcards

Flashcards in Exam 3: Autoimmune diseases Deck (17):
1

Effects of Gold compounds to treat autoimmune diseases

Decrease inflammation
Slows progression of bone and articular destruction

2

T or F, gold compounds are expensive to buy and administer

True

3

Name the Gold compound drugs used to treat RA

- aurothioglucose
- auranofin (Ridaura)
- gold sodium thiomalate (Aurolate)

4

T or F, There is a low incidence of toxicity in gold compounds

False, High incidence = requires intensive monitoring
Symptoms
- Dermatitis with mucosal ulcerations
- Proteinuria
- Neutropenia
- Thrombocytopenia

5

List the oral complications with Gold

Infection
Delayed healing
Prolonged bleeding
Glossitis
Aphthous stomatitis
Blue-black intramural pigmentation

6

Indications for Immunosuppressive drugs

Used in cases of refractory RA

7

List the immunosuppressive drugs

azathioprine (Imuran, Azasan)
cyclophosphamide (Cytoxan)
cyclosporine (Sandimmune, Gengraf, Neoral, Restasis)

8

What immunosuppressant is used in dentistry with prednisone for major oral mucosal problems?

azathioprine
- used for severe erosive lichen plans, major aphthous stomatitis, erythema multiforme, benign mucous membrane pemphigoid

9

cyclophosphamide (Cytoxan) is a part of what two drug classes?

Immunosuppressant
Antineoplastic drug

10

Indication for cyclophosphamide (Cytoxan)

Used for severe RA

11

Side effects of Cytoxan

alopecia
infertility
GI
blood dyscrasias

12

Indication for cyclosporine

- Used primarily to prevent rejection of organ transplants
- Used for severe active RA that is not responsive to methotrexate

13

When is cyclosporine contraindicated

For RA if have abnormal renal function, uncontrolled hypertension, malignancies

14

3 uses for synthetic glucocorticoid medications

1. Autoimmune diseases
2. Immunosuppressive therapy in organ transplant patients
3. Respiratory disease management

15

List the salivary stimulating medications

pilocarpine (Salagen)
cevimeline (Evoxac)

16

Elevated BP in autoimmune patients may be due to what?

Chronic pain

17

Do autoimmune patients require Antibiotic premedication?

Most DO NOT require antibiotic premedication
ADA task force recommendations for patients with prosthetic joints