Exam 4: Smoking Cessation Flashcards Preview

Pharmacology II > Exam 4: Smoking Cessation > Flashcards

Flashcards in Exam 4: Smoking Cessation Deck (13):
1

List the 3 types of drugs that can be used for smoking cessation therapy

1. Nicotine replacement therapy
2. bupropion (Zyban) - Dopamine reuptake inhibitor
3. varenicline (Chantix)

2

What effect does nicotine have on the vascular system

Potent vasoconstrictor

3

List the contraindications of Nicotine replacement therapy

1. Hypersensitivity to nicotine
2. Smokers folloing Post-MI
3. Life-Threatening Arrythmias
4. Angina
5. Active TMD (chewing gum)
6. Pregnancy
7. Non-smokers (aka children wanting to get a buzz)

4

Why are patients not allowed to smoke while taking nicotine?

Patients must completely stop smoking prior to therapy
**nicotine raises cardiovascular risk, so can't smoke at same time

5

List the forms that nicotine can be given in

Gum
Lozenge
Inhaler
Nasal Spray

6

How long does one take nicotine replacement therapy aids

Used in step-down approach for 7-12 weeks (3 months)
- dose used is less than what is obtained through smoking
- decreasing dosage w/ time

7

What is the MOA of buPROPion (Zyban)

Dopamine reuptake inhibitor
(Antidepressant = Wellbutrin)

8

What are the risks with buPROPion?

1. Risk for seizures: avoid alcohol and other drugs
2. Risk of treatment emergent hypertension with concurrent patch use.
3. Adverse psychological events

9

How long does treatment with buPROPion last?

7-12 weeks

10

What is the MOA with varenicline (Chantix)

Partial neuronal alpha4 B2 nicotinic receptor agonist
- occupies nicotine receptor sites in the brain

11

Action of varenicline has what effects?

- Prevents nicotine stimulation of mesolimbic dopamine system associated with nicotine addiction
- Stimulates dopamine activity, but to a much lesser extent than nicotine does.
**Results in decreased craving and withdrawal symptoms

12

Name the side effects with varenicline

Oral: xerostomia and taste alteration
General: insomnia, headache, abnormal dreams, nausea, suicidal thoughts, aggressive behavior, adverse cardiac events

13

When are the side effects of varnicline increased?

when the drug is used with nicotine replacement therapy