Flashcards in Exam 4: Smoking Cessation Deck (13):
List the 3 types of drugs that can be used for smoking cessation therapy
1. Nicotine replacement therapy
2. bupropion (Zyban) - Dopamine reuptake inhibitor
3. varenicline (Chantix)
What effect does nicotine have on the vascular system
List the contraindications of Nicotine replacement therapy
1. Hypersensitivity to nicotine
2. Smokers folloing Post-MI
3. Life-Threatening Arrythmias
5. Active TMD (chewing gum)
7. Non-smokers (aka children wanting to get a buzz)
Why are patients not allowed to smoke while taking nicotine?
Patients must completely stop smoking prior to therapy
**nicotine raises cardiovascular risk, so can't smoke at same time
List the forms that nicotine can be given in
How long does one take nicotine replacement therapy aids
Used in step-down approach for 7-12 weeks (3 months)
- dose used is less than what is obtained through smoking
- decreasing dosage w/ time
What is the MOA of buPROPion (Zyban)
Dopamine reuptake inhibitor
(Antidepressant = Wellbutrin)
What are the risks with buPROPion?
1. Risk for seizures: avoid alcohol and other drugs
2. Risk of treatment emergent hypertension with concurrent patch use.
3. Adverse psychological events
How long does treatment with buPROPion last?
What is the MOA with varenicline (Chantix)
Partial neuronal alpha4 B2 nicotinic receptor agonist
- occupies nicotine receptor sites in the brain
Action of varenicline has what effects?
- Prevents nicotine stimulation of mesolimbic dopamine system associated with nicotine addiction
- Stimulates dopamine activity, but to a much lesser extent than nicotine does.
**Results in decreased craving and withdrawal symptoms
Name the side effects with varenicline
Oral: xerostomia and taste alteration
General: insomnia, headache, abnormal dreams, nausea, suicidal thoughts, aggressive behavior, adverse cardiac events