Exam 4: Gout Flashcards Preview

Pharmacology II > Exam 4: Gout > Flashcards

Flashcards in Exam 4: Gout Deck (11):

Chronic gout may cause what?

Joint destruction
Decreased Kidney function


What is Asymptomatic hyperuricemia

The state of elevated levels of uric acid in the blood without symptoms of gout


2 types of gout

1. Excessive production of uric acid
2. Reduced excretion of uric acid


Symptoms of Gout

1. Affects one joint at a time, most commonly big toe
2. Sudden pain, swelling, redness, warmth and stiffness
3. Low-Grade fever may be present
4. Skin over joint is swollen, tender and sore


Gout has what 4 distinct stages

1. Asymptomatic - high levels of uric acid but no joint complaints
2. Acute - acute complaints occur for a brief period
3. Intercritical - No pain or swelling of joints. Patient is relatively symptom-free
4. Chronic - Gout attacks may become frequent. Tophi formation may be seen.


Indication of colchicine (Colcrys)

treatment of acute attack of gout


Mechanism of colchicine

inhibition of neutrophil migration and phagocytic activity in inflamed joints, which in turn inhibits neutrophil engulfment of uric acid crystals, preventing release of destructive lysosomal enzymes into extracellular environment.


indication of allopurinol (Zyloprim)

1. used to prevent formation of excessive uric acid, and lower blood and urine concentrations
* not for asymptomatic hyperuricemia
2. Also used during chemo and radiation because death of many cells results in large amounts of uric acid prescursors


Mechanism of action for probenecid (Benemid)

Increases the excretion of uric acid = uricosuric agent


Indication of probenecid

Management of chronic gout
acute gout attacks increase in frequency or severity


What non-opioid pain relievers may be used in management of gout

- short-term use
Relieve pain, tenderness and swelling of affected joints