Flashcards in Feast or Famine Deck (12):
Effect of NPY on appetite? Of alpha-MSH?
NPY increases food intake.
alpha-MSH increases satiety.
Is obesity just lots of adipose tissue?
No, there's fat deposition in many organs.
Where is leptin produced? What happens when you don't have it?
Leptin is produced in fat cells.
If not present, no negative feedback from adipose to suppress appetite -> just keep feeding and become obese.
What happens if melanocortin-4 is knocked out?
Why is being sarcopenic (not much muscle mass) bad?
Less muscle means you can't take up glucose as well.
Why are extra-adipose triglycerides bad?
ROS...ER stress... inflammation... impairs insulin signaling -> insulin resistance
What's the most effective form of bariatric surgery for weight loss?
Roux-en-Y gastric bypass to more distal small intestine.
What is dumping syndrome?
Orthostatic hypotension / hypoglycemia in response to feeding.
3 cytokines that can drive cachexia?
TNF, IL-1, IL-6
3 drivers of anabolism in skeletal muscle?
3 pathways for catabolism in skeletal muscle?