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Flashcards in Feast or Famine Deck (12):
0

Effect of NPY on appetite? Of alpha-MSH?

NPY increases food intake.
alpha-MSH increases satiety.

1

Is obesity just lots of adipose tissue?

No, there's fat deposition in many organs.

2

Where is leptin produced? What happens when you don't have it?

Leptin is produced in fat cells.
If not present, no negative feedback from adipose to suppress appetite -> just keep feeding and become obese.

3

What happens if melanocortin-4 is knocked out?

Obesity.

4

Why is being sarcopenic (not much muscle mass) bad?

Less muscle means you can't take up glucose as well.

5

Why are extra-adipose triglycerides bad?

ROS...ER stress... inflammation... impairs insulin signaling -> insulin resistance

6

What's the most effective form of bariatric surgery for weight loss?

Roux-en-Y gastric bypass to more distal small intestine.

7

What is dumping syndrome?

Orthostatic hypotension / hypoglycemia in response to feeding.

8

3 cytokines that can drive cachexia?

TNF, IL-1, IL-6

9

3 drivers of anabolism in skeletal muscle?

Follistatin
IGF-1
Androgens

10

3 pathways for catabolism in skeletal muscle?

Autophagy
Ubiquitin
Myostatin

11

3 features of management of cachexia?

Controlled re-feeding.
Treat underlying cause.
Rev up anabolism? -> megesterol, cannabinoids, GNRH, myostatin inhibitors...