Fever + CRP (Inflammation)

Question 1

pathogenesis of fever

Answer 1

1) body’s IR triggered by exogenous pyrogens which trigger endogenous pyrogens that bind to PGE2
2) PGE2 sends signal to hypothalamus which then increases temp set points via cAMP

Question 2

C-reactive protein (CRP)

Answer 2

• protein synthesized (secreted by liver during inflm

- impt serum marker for inflm

Question 3

serum marker

Answer 3

components in blood that can determine where disease is taking place/the extent of disease damage

Question 4

Fx of CRP

Answer 4

aids complement in defense

Question 5

non-specific marker

Answer 5

indicates inflm is occurring but not WHERE inflm is occurring (ex. CRP)

Question 6

what other marker is CRP for

Answer 6

atherosclerosis (inc lvls of CRP)