Friday Wk 6 Mixed 2 Flashcards
chronic HTN in pregnant woman is SBP > 140 or DBP > 90 prior to __ gestation
Gestational HTN occurs after __ and has no proteinuria/end organ damage
Preeclampsia is GHTN w proteinuria or __
Eclampsia requires __ seizures
pathology is due to abnormal __ w hypoxia/ischemia
releases antiangiogenic factors and endothelial __
results in __ w rise in BP and damage to CNS w HA/visual probs and ab pain
smoking upregulates / elastase and inactivates AAT
HOMEOBOX GENES ENCODE FOR __
proper morphogenesis is needed for T, O, E to be incorrect position
20w 20w end organ damage grand mal placental vasculature injury PROTEINURIA
PMN/macrophage
DNA binding transcription factors
tissues, organs, structural elements
__ is adenosine receptor antag and PDE inhib for asthma
metabolized by __ thus has many interaction
toxic SE include T, I, S, gi probs and A
V is anothe p450 inhib
pancytopenia w out HSM is __
deficient in CD34 __
use __ for methanol/ethylene glycol overdose
inhibits __ dehydro
transport maximum in the kidney determined by capacity of transporters for __ reabsorption
glycosuria develops at plasma levels greater than __
Cystatin C is filtered by glomeruli and metabolized by renal _ cells
variable __
Creat/Inulin conc in urine is __ as filtered
PAH conc in urine is __ than filtered due to secretion
theophylline
p450
tremors, insomnia, seizures, arrhythmias
Verapamil
APLASTIC ANEMIA
hematopoeitic stem cells
FOMEPIZOLE
alcohol
active 200 tubule reabsorption same HIGHER
R__ is melatonin agonist safe for elderly
Antipsychs in elderly increase risk of __ and death via dementia
look for __ vitals in pt w substance induced manic episode
can use arterial __ to stop active bleeding from sigmoid colon
distal transverse, descending/sigmoid colon and rectum are __ derived
thus receives __ supply
vein drains to / vein
___ rectal artery is a branch of IMA
E6 binds p53 and __ it for degredation
E7 binds Rb and displaces it from __
upregulation of RAS/BRAF code for __ proteins
PDGF upregulated in malignant transformation of _
ramelteon
STROKE
HIGH
embolization hindgut IMA splenic/portal superior
ubiquitinates
transcription factor
signal transducing proteins
glioblastoma
barking cough in child w URI indicates __
inflamed __ tissue obstructs airways leading to stridor
bronchial constriction in asthma due to __ activation w release of mediators
can have late phase obstruction due to mediators such as E, B, N, T
C/N inhibit degranulation and release of mediators
uptake of exogenous DNA fragments and incorporation into genome is __
seen in S, H, N, B
__ uses phage to infect bacterium after incorporating it into genome
__ is one way transfer by F factor
transfer __ DNA strand w F factor w synthesis of comp strand
laryngotracheobronchitis
subglottic
mast cell
Eosinophils, basophils, PMN, t cells
cromolyn, nedocromil
transformation
strep, haemophilus, neisseria, bacillus
Transduction
conjugation
single strand
Botulinum toxin characteristically causes / poisoning w 3Ds
toxin is heat __ thus killed w heat
toxin taken into cells via __
Diastolic HF due to impaired __ and inc ventricular wall stiffness
determined by __ of LV
Systolic HF has inc LV __ and LVEDP
__ dz is debranching enzyme def affecting liver/muscle
sx include H, H, K as well as muscle weakness and __
hepatic __ is common w no fatty infiltrate
see cytosolic accumulation of __ w short outer chains
glycogen __ cleaves 1, 4 a glycosidic linkages
when 4 residues remain, debranching enzyme acts as G__ to transfer outer 3 residues to nearby branch
then __ removes remaining residue to produce free glucose/linear strand
Von Gierke (G6P def) only affects \_\_ cardinal feature is hepatic _
nicotinic, muscarinic
diplopia, dysphagia, dysphonia
labile
endocytosis
relaxation
compliance
volume
cori
hypoglycemia, Hepatomegaly, ketosis, hypotonia
fibrosis
glycogen
phosphatase
glucosyltransferase
a 1, 6 glucosidase
LIVER
STEATOSIS
__ dz is liver GP deficiency
see hypoglycemia, ketosis, hepatomegaly w __ structured gycogen
__ dz has low muscle lactate and normal glycogen
IgE/IgG bind Fc receptors on \_\_ w parasite antigen leads to \_\_ cytotoxicity or presentation to MHC class 2 also release products for _ phase type 1 HS rxn immediate type 1 HS rxn due to _/_
Mallory weiss syndrome is __ tear due to inc intragastric pressure
leads to __
Boorhaave is __ tear w inc pressure
due to esophageal / leakage
presents w chest __ and fever, septic shock
Diarrhea causes loss of _ and thus normal GAP MA
Hers
NORMAL
McArdle
eosinophils
Antibody dependent CM
LATE
mast cells/basophils
mucosal HEMATEMESIS transmural AIR/FLUID PAIN
bicarbonate
Water is reabsorbed in PCT __ while electrolytes reabsorbed __
in absence of ADH, collecting ducts are __ to water
primary amenorrhea is failed menarche by __
secondary is __ menstruation in premen woman who previously had them
Fxnal hypothalamic amenorrhea is due to a lack of __ that stops pulsatile GnRH
pons has the __ a pigmented brainstem nucleus
located posterior rostral near lateral floor of __
stimulates release of __
useful for M, A, C, Autonomic fxn
w bilateral hemorrhage, pt has coma due to lack of __
also see __ posturing and pinpoint pupils
__ produced in VT and SNPC of MIDBRAIN
ML pathway for __
MC pathway for __
NS for coordinating _ and TI path to inhibit __
passively, activeky
IMPERMEABLE
15
failed
LEPTN
locus ceruleus 4th ventricle NE mood, arousal, cognition reticular formation, extensor
Dopamine cognition behavior voluntary movement prolactin
__ is opioid peptide to modulate pain
produced in __ gray and dorsal horn of SC
high conj bilirubin indicates __ dz as bilirubin refluxes into plasma
unconj due to inc bilirubin __ or slowed conjugation
__ syndrome due to defect in UDP glucuronyltransferase
brought on by __ and all other labs normal
pt w LEMS likely has __ sx like dry mouth/impotence
pts have H/A and INCREMENTAL response to stimulation
Cavernous hemangioma occurs in brain __ above tentorium
pt often has __ and neuro defects
tendency to __ w bright mass on CT
Gq activates __ to convert PIP2 to IP3/DAG
IP3 inc intracellular __ and w DAG activates PKC
thus, blocking Ca release impairs activity of __
Dynorphin
periaqueductal
cholestatic
prodxn
GILBERT
trigger
autonomic
hypo/areflexia
PARENCHYMA
seizures
bleed
Phospholipase C
Calcium
PKC
ethanol induces __ secretions w high protein/low fluid content
these secretions __ that obstuct panc ducts
also causes spasms of __
can distinguish alcohol as etiology w high __ independent of FOLATE DEF
clasp knife spasticity indicates _ lesion
in HD, NMDA receptors bind __ and cause neuronal deat
GABA/Ach/SP are __
Dopamine is __
neurons may be lost in __
damage to __ of medulla leads to myoclonus
after slapped cheek rash, EI becomes lacy, __ rash on trunk
due to __ deposition w high antibody levels
replicates in RBC precursors in __
pancreatic
precipitate
sphincter of oddi
MCV
UMN
glutamate
low
high
putamen
nucleus ambiguus
reticular
immune complex
bone marrow
__ virus replicates in intestinal epithelial cells
Roseola replicates in __
Folate is needed in __ synthesis of purines/pyrimidines
pancreatic enzymes needed to cleave _ from B12 allowing it to interact w IF
__ xanthomas appear abruptly as plasma TG/LDL inc
__ xanthomas in skin folds are strongly assc w PBC
composed of __ w foamy cytoplasm
lower finers of OT carry info from __ retina to Meyers loop and to __ gyrus of striate cortex
lesion results in __ defect
upper fibers of OT carry info from upper retina to parietal lobe and __ gyrus of striate cortex
lesion leads to __ defect
Rotavirus
mature lymphocytes
DNA
R binder
eruptive
plane
macrophages
upper lingual upper cuneus lower
lesion at OT leads to __
__ is most common delayed milestone
need //_ eval
at 12m, pt should \_\_ well and begin walking can follow \_\_ commands at 18m, can run and _ ball builds \_\_ and removes clothes identify 1+ body part and \_\_ words understands \_\_ and pretend 2 yrs goes upstairs w \_\_ copies a \_\_ vocab > \_\_ words w 2 word phrases follow 2 step commands, can \_\_ play begin \_\_
3 yrs can __ w alternating feet
ride __ and copy circle/use utensils
__ word sentences
knows /
at 4 can _ on 1 foot, copy __
identify __ w good speech
cooperative __
at 5 can S and catch ball
copy a __ and tie shoes
count to __ w 5word sentences
completes __
contra homonyous heianopsia
stand 1 step kick tower 25 mine both feet line 50 pretend, toilet training
walk upstairs
trike
4
age/gender
balance, cross
color
play
skip
square
10
toilet training
B2 agonists mediate __ uptake, thus only __ BB promote hyperkalemia
NSAIDs inhibit _ synth w dec renin/aldo release
anything that dec release of __ leads to hyperKalemia
A/T/S are K sparing diuretics that inc K levels
TTP due to deficiency of _
normally cleaves __ multimers
if uncleaved, they are more __ w schistocytes forming
tx w P/G/R
whipples triad for hypogly- sx, low __ and relief w inc levels
use __ drug assay to differentiate drug from insulinoma
K, NONSELECTIVE
PG
ALDOSTERONE
amiloride, triamterene, spironolactone
vWF
thrombotic
plasma exchange, GC, rituximab
blood glucose
hypoglycemic
