Gastric Cancer Flashcards
1
Q
Epidemiology?
A
Most common in South American and Japan
More common in mals
2
Q
Aetiology?
A
H.pylori
Smoking
Atrophy of stomach muscle (Caused by resection or H.pylori infection)
3
Q
Symptoms?
A
Dyspepsia Abdominal pain Emesis Anorexia Early Satiety Upper GI Haemorrhage Weight loss Mass Virchow's Node Anaemia
4
Q
Pathology?
A
An adenocarcinoma in the mucous secreting cells of the gastric pits. Most commonly caused by mutation of the tumour supressing p53 gene
5
Q
Investigations?
A
Endoscopy and Biopsy CT Scan (Staging)
6
Q
Alarm Features?
A
>55 Dysphagia GI Blood Loss Vomiting Weight Loss Upper Abdominal Mass Anaemia
7
Q
Treatment
A
Surgery - Improves survival and symptoms: Resection of the stomach Total Gastrectomy for proximal lesions Partial Gastrectomy of distal lesions Chemotherapy Radiotherapy
8
Q
Prognosis?
A
5 Year survival is 10-15%
