Gastric cancer- clinical and effect of H pylori Flashcards Preview

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Flashcards in Gastric cancer- clinical and effect of H pylori Deck (6):

What are the symptoms?

Dyspepsia + alarm symptoms:
Weight loss
Recurrent vomiting


Is family history common in gastric cancer?

Yes, in first degree relatives


What has been noticed about patients with H pylori infection who develop peptic ulcer disease in relation to gastric cancer?

They are somehow protected from gastric cancer


How does H pylori inhibit gastric acid secretion?

The effect of body inflammation induced by H pylori
IL-1B production is stimulated in H pylori gastritis
This is a powerful inhibitor of acid secretion
It acts on the ECL cell to inhibit histamine release and on the parietal cell to inhibit HCl release


What is a potential host genetic factor predisposing to hypochlorhydric response to H pylori?

Il-1 beta gene- there is IL-1 beta in H pylori gastritis. IL-1B is a powerful acid inhibitor.
There are recognised polymorphisms of the IL-1B gene with differing pro-inflammatory activities.


What is the effect of differing IL-1B pro inflammatory activities on the development of gastric cancer, caused by H pylori?

H pylori infection --> mucosal inflammation --> IL-1B inflammatory response Host genotype :
1 of two results: If there is a pro inflammatory response, there can be acid hyposecretion and body predominant gastritis, which becomes atrophic gastritis, and can become cancer.
If the host does not have a proinflammatory IL-1B phenotype, there is normal or high acid secretion. The gastritis is antral predominant and there is no cancer (or duodenal cancer).

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