Flashcards in Gastric cancer- clinical and effect of H pylori Deck (6):
What are the symptoms?
Dyspepsia + alarm symptoms:
Is family history common in gastric cancer?
Yes, in first degree relatives
What has been noticed about patients with H pylori infection who develop peptic ulcer disease in relation to gastric cancer?
They are somehow protected from gastric cancer
How does H pylori inhibit gastric acid secretion?
The effect of body inflammation induced by H pylori
IL-1B production is stimulated in H pylori gastritis
This is a powerful inhibitor of acid secretion
It acts on the ECL cell to inhibit histamine release and on the parietal cell to inhibit HCl release
What is a potential host genetic factor predisposing to hypochlorhydric response to H pylori?
Il-1 beta gene- there is IL-1 beta in H pylori gastritis. IL-1B is a powerful acid inhibitor.
There are recognised polymorphisms of the IL-1B gene with differing pro-inflammatory activities.