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Flashcards in GI Drugs Purpose and Actions Deck (15):
1

H2 Antagonists

Purpose: short term treatment of GERD, active duodenal ulcers, benign gastric ulcer

Actions: selectively block histamine 2 receptor sites; this blocking leads to a reduction in gastric acid secretion and reduction in overall pepsin production

2

Antacids- aluminum salts

Purpose: symptomatic relief of upset stomach associated with hyper-acidity and hyperactivity

Actions: Neutralizes stomach acid by direct chemical reaction;includes aluminum, calcium, magnesium, and sodium bicarbonate

3

Proton pump inhibitors

Purpose: short term treatment of active duodenal ulcers, GERD, erosive esophagitis, benign active gastric disease

Actions: act at specific secretory surface receptors to prevent the final step of acid production and thereby decrease the level of acid in the stomach

4

GI Protectant Agents

Purpose: promote ulcer healing

Actions: forms and ulcer-adherent complex at duodenal ulcer sites, protecting the sites against acid, pepsin, and bile salts

5

Prostaglandins

Purpose: prevention of NSAID-induced gastric ulcers; treatment of duodenal ulcers

Actions: inhibits gastric acid secretions and increases bicarbonate and mucous production in the stomach

6

Digestive Enzymes: Saliva and pancreatic enzymes

Purpose: saliva- people with dry mouth (stroke, salivary disorders, conditions of the head and neck, anticholinergics);
pancreatic enzymes- cystic fibrosis

Actions: saliva substitute- contains electrolytes and carboxymethylcullulose to act as a thickening agent in dry mouth conditions; pancreatic enzymes are replacement enzymes that help the digestion and absorption of fats, proteins, and carbs

7

Actions of Laxatives: chemical stimulants

Actions: chemically irritate the lining of the GI tract

8

Actions of Laxatives: bulk stimulants

Actions: cause the fecal matter to increase in bulk

9

Actions of Laxatives: lubricants

Actions: help the intestinal contents move more smoothly through lubrication

10

Purpose of all Laxatives

-short term relief of constipation
-prevent straining when it is clinically undesirable
-evacuate the bowel for diagnostic procedures
-removal of ingested poisons

11

GI stimulants

Purpose: ?

Actions: Blocks dopamine and increases Ach to stimulate parasympathetic activity within the GI tract; increases GI secretions and motility, anti N/V

12

Antidiarrheals

Purpose: relief of symptoms of acute or chronic diarrhea, reduction of volume of discharge from ileostomies, prevention and treatment of travelers diarrhea

Actions: slow the motility of the GI tract through direct action on the lining of the GI tract

13

Antiemetics Phenothiazines

Purpose: treatment of nausea and vomiting, hiccoughs

Actions: depresses various areas of the CNS, anticholinergic

14

Antichilinergics/ Antihistamines

Purpose: prevention and treatment of N/V

Actions: Anticholinergics that act as antihistamines and block the transmission of impulses to the CTZ in the medulla

15

Antiemetics Serotonin 5-HT2 Receptor Blockers

Purpose: control of nausea and vomiting, esp. chemo

Actions: block those receptors associated with nausea and vomiting in the CTZ and locally