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Flashcards in GI IV Deck (49)
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1

What is the liver covered in?

connective tissue capsule called Glisson's capsule

2

What lies external to Glisson's capsule?

mesothelium of visceral peritoneum

3

What supports hepatocytes?

delicate reticular framework (type III collagen fibers)

4

Describe a classic hepatic lobule

stack of hexogonal plates of hepatocytes, sinusoids and central vein

5

What's in portal canals?

connective tissue, portal triad, lymphatic vessels and autonomic nerve fibers

6

Where are portal canals found?

angles of the liver lobule (3-6 portal canals)

7

What's in a portal triad?

1) branches of hepatic artery
2) portal vein
3) bile duct

8

What is another name for periportal space?

space of Mall

9

Where is periportal space located?

between connective tissue and adjacent hepatocytes

10

What is presumed to be the site of lymph origin?

periportal space

11

Are lymphatic vessels part of the portal triad?

NO

12

What type of epithelium do bile ducts have?

simple cuboidal

13

What does it mean by dual blood supply to liver?

portal vein (nutrients) provides 75% of the blood while hepatic artery proper (oxygen) provides the rest

14

What are the three features to sinusoids?

1) discontinuous endothelium with large fenestrations and discontinuous basal lamina
2) Kupffer cells
3) Perisinusoidal space (of Disse)

15

What are Kupffer cells?

hepatic macrophages (professional phagocytic cells that line the capillaries)

16

What is found in the perisinusoidal space (of Disse)?

1) hepatic stellate cell
2) microvilli of hepatocytes

17

What are other names for hepatic stellate cell?

perisinusoidal cell and cell of Ito

18

What's the function of hepatic stellate cell?

contractile and CT elaboration

19

What's another name for central vein?

terminal hepatic venule

20

What's the purpose of microvilli in the sinusoidal capillaries?

increases surface area

21

How many zones are in hepatic acinus?

3

22

Which zone is this?
1) increased O2
2) decreased CO2
3) decreased metabolic waste products
4) increased nutrients
5) bile stasis, iron toxicity and alfatoxin (perilobular damage)
6) regenerative capacity

Zone 1

23

Which zone is this?
1) decreased O2
2) increased CO2
3) increased metabolic waste products
4) decreased nutrients
5) first to show fat accumulation
6) more susceptible to damage

Zone 3

24

Which zone is susceptible to ischemic-induced necrosis?

zone 3

25

Which zone is more susceptible to several drug (such as acetaminophen) and toxic reactions? Why?

zone 3 because more detoxification reactions occur there

26

Which zone will you find most of these enzymes?
glucose-liberating enzymes

zone 1

27

Which zone will you find most of these enzymes?
fatty-acid synthesizing enzymes

zone 3

28

Which zone will you find most of these enzymes?
fatty acid oxidation enzymes

zone 1

29

Which zone will you find most of these enzymes?
glycolysis enzymes

zone 3

30

Which zone will you find most of these enzymes?
detoxification enzymes

zone 3