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Flashcards in Male Reproductive Deck (77)
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1

What does the male reproductive system consists of (5)?

1) testis
2) genital ducts
3) seminal vesicle
4) prostate
5) penis

2

What are the accessory glands (2)?

1) seminal vesicle
2) prostate

3

Dense irregular collagenous connective tissue capsule that encloses each testis

tunica albuginea

4

Thickened portion of the tunica albuginea where epididymis attach

mediastinum testis

5

Mediatinum testis gives rise to incomplete connective tissue septa that radiate into the testis and further subdivides into...

~250 lobules called lobuli testis

6

Layer of loose CT deep to the tunica albuginea and has a rich vascular supply known as the vascular capsule of the testis

tunica vasculosa

7

What does each lobule of lobuli testis contain (3)?

1) 1-4 seminiferous tubules
2) interstitial cells of Leydig
3) loose CT stroma

8

What's the function of seminiferous tubules?

site of where spermatogonia differentiate into spermtazoa

9

What's the function of interstitial cells of Leydig?

produce and secrete testosterone

10

Where are interstitial cells of Leydig in reference to seminiferous tubules and CT stroma within lobuli testis?

interstitial cells of Leydig are scattered within the CT stroma, which surrounds seminiferous tubules

11

What are the three layers to seminiferous tubules?

1) tunica propria
2) basal lamina
3) seminiferous epithelium

12

What is in the tunica propria of seminiferous tubules?

thin CT layer consist of type 1 collagen with 3-5 layers of myoid cells

13

What are myoid cells?

they are contractile smooth muscle cells within the tunica propria of seminiferous tubules

14

What's the function of myoid cells?

rhythmic contractions that produce peristaltic waves to move spermatozoa through the seminiferous tubules

15

Does basal lamina of seminiferous tubules contain cells?

NO, it is acellular

16

What are the two cell types found in seminiferous epithelium?

1) spermatogenetic cells
2) Sertoli cells

17

Where does differentiation of spermatogenetic cells start and end within the seminiferous epithelium?

they start at the periphery of the epithelium then progress toward the lumen

18

Describe the appearance of Sertoli cells

tall, columnar cells that have highly folded apical and lateral cell membrane
nuclei are clear, ovoid or triangular
prominent nucleolus
Note: these cells run the entire length of the epithelium (unlike spermatogenetic cells)

19

Do Sertoli cells replicate?

Not after puberty

20

What type of cellular junctions do Sertoli cells have?

extremely tight zonula occludens junctions

21

What's the purpose of the tight junctions in Sertoli cells?

they bind the lateral cell membranes of adjacent Sertoli cells together to compartmentalize the seminiferous epithelium into 2 compartments

22

What are the two compartments that is compartmentalized by the tight junctions?

1) basal epithelial
2) luminal

23

What is the blood-testis barrier?

occludens jucntions create this barrier to separate the antigenic spermatogenetic cells from the immune system

24

Why are spermatogenetic cells antigenic and specifically which ones?

they are haploid (1n):
secondary spermatocytes (1n-2d)
spermatids and sperm (both 1n-1d)

25

What can phagocytose spermatid remnants?

Sertoli cells

26

What does testosterone bind to and what releases it?

ABP (androgen-binding protein) released by Sertoli cells

27

What's the purpose of ABP?

promotes spermatogenesis

28

Which compartment of seminiferous epithelium is considered immuno-priviledged? Why?

luminal compartment because it contains the spermatogenetic cells

29

What's inside the basal epithelial compartment of seminiferous epithelium?

1) spermatogonia and early primary spermatocytes
2) blood, ions, and other nutrients (aa's, carbs and proteins)

30

What is the most immature spermatogenetic cell called?

spermatogonia