Flashcards in GI random facts Deck (49)
What affects zone 2 of the liver?
What affects zone 3 of the liver?
Ischemia, metabolic toxins, alcoholic hepatitis
What are the spermatic cord fascia layers and where do they come from?
Extern spermatic fascia from the external oblique, cremaster in muscle and fascia from the internal oblique, and internal spermatic fascia from the transversal is fascia
What increases gastrin secretion?
Chronic atrophic gastritis, Z-E syndrome, and chronic PPI use
What are the effects of CCK?
⬆️ pancreatic secretion, ⬆️ gallbladder contraction,⬆️ sphincter of Oddi relaxation, decrease gastric emptying
How does CCK have its effects?
Acts on neural muscarinic pathways to cause pancreatic secretion
Watery diarrhea, hypokalemia, and achlorhydria
Regulators of gastric parietal cell and how they work
Ach (M3) and gastrin (CCKa) activate a Gq receptors increasing IP3 and Ca. Histamine (H2) activates a Gs protein increasing cAMP. Prostaglandins/misoprostol and somatostatin activate a GI protein, inhibiting cAMP.
Where is iron absorbed?
Where is folate absorbed
Where is B12 absorbed?
Terminal ileum with bile salts, requires intrinsic factor
What catalyzes the rate limiting step in bile synthesis?
What is the body's only mechanism of cholesterol elimination?
How does bile have antimicrobial activity?
Via membrane disruption
What catalyzes the conjugation of bilirubin?
What causes achalasia?
Loss of myenteric (Auerbach) plexus
What does achalasia predispose you to?
Squamous cell carcinomA
Histopathology of esophageal squamous cell carcinoma
Solid nests of neoplasticism squamous cells with abundant eosinophilia cytoplasm and distinct borders. Areas of keratinization and the presence of intercellular bridges
Gastric hyperplasia of mucosa causes hypertrophied rugae, excess mucus production with resultant protein loss and parietal cell atrophy with decreased acid production. Precancerous
What affects zone 1 of the liver?
Which types of colonic polyps are non-neoplastic, neoplastic, and premalignant?
Hyperplastic and hamartomatous are non-neoplastic, adenomatous is neoplastic, and serrated is premalignant
Which type of adenomatous polyp has more malignant potential: villous or tubular?
How are serrated polyps premalignant ?
Via CpG hypermethylation phenotype pathway with microsatellite instability and mutations in BRAF
"Saw tooth" pattern of crypts
AD, mutation of APC on chromosome 5q
FAP plus osseous and soft tissue tumors, congenital hyper trophy of retinal pigment epithelium, impacted/supernumerary teeth
FAP plus malignant CNS tumor
AD, numerous hamartomatous polyps plus hyperpigmentation, increased risk of colorectal, breast, stomach, small bowel, and pancreatic cancer.
Pigmented mucocutaneous Macules on the buccal mucosa