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Flashcards in Repro Random facts Deck (97)
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1

What causes a cleft palate?

Failure of fusion of the two lateral palatine processes or failure of fusion of lateral palatine processes with the nasal septum and/or median palatine process

2

What causes testes development?

SEY gene in Y chromosome produces testes determining factor

3

What secretes MIF?

Sertoli cells

4

Action of MIF

Suppresses development of paramesonephric ducts

5

What does the mesonephric duct become and what stimulates it to become this?

Seminal vesicles, epididymis, ejaculatory duct, ductus deferens. Stimulated by androgens from Leydig cells

6

Primary amenorrhea in a woman with fully developed secondary sexual characteristics

Mullerian agenesis

7

What causes development of the prostate?

DHT (so 5-alpha-reductase deficiency causes male internal genetalia, ambiguous external genetalia until puberty)

8

What does the genital tubercle become in men?

Glans penis and corpus cavernosum and spongiosum

9

What is the female homolog of the prostate gland?

Urethral and para urethral glands (of Skene)

10

What is the male homolog of the greater vestibular glands (of Bartholin)

Bulbourethral glands of Cowper

11

What is hypospadias associated with?

Inguinal hernia and cryptorchidism

12

Mehta causes epispadias?

Faulty positioning of genital tubercle

13

What do the urogenital folds become?

Ventral shaft of penis in men and labia minora in women

14

What causes a cleft lip?

Failure of fusion of the maxillary and medial nasal processes (formation of primary palate)

15

Lymph drainage of the proximal vagina/uterus

Obturator, external iliac, and hypogastric nodes

16

What is the other name for the suspensory ligament of the ovary?

Infundibulopelvic ligaments

17

What is the round ligament?

Connects the uterine funds to labia majora. Derivative of the gubernaculum. Travels through round inguinal canal; above artery of Sampson

18

Affects of temperature on Sertoli cells

Increased temperature causes decreased sperm production and decreased inhibin

19

Where are the Leydig cells?

In the interstitial between seminiferous tubules

20

What does androgen binding protein do and what secretes it?

Secreted by Sertoli cells, maintains local levels of testosterone (by binding and making it less lipophilic so it stays in the tubule)

21

What types of estrogen are made by the ovary, placenta, and adipose tissue and what is the potency?

Ovary: 17-beta-estradiol; placenta: estriol; adipose tissue: estrone via aromatization. Potency: Estradiol> estrone> estriol

22

Effect of SHBG on cholesterol

Increased transport proteins (SHBG) causes increased HDL and decreased LDL

23

Which cells in the female make androgens?

Theca interna cells

24

What enzyme is used to make androgens from cholesterol

Desmolase

25

Which cells make estrogens from androgens

Grnaulosa cells

26

Where are estrogen receptors located?

Cytoplasm (translate to the nucleus when bound by estrogen)

27

Regulation of prolactin by estrogen and progesterone

Estrogen stimulates prolactin secretion, fall in progesterone after delivery disinhibits prolactin

28

When is follicular growth the fastest?

During the 2nd week of the proliferative phase

29

Where is meiosis I arrested and until when?

Arrested in prophase I for years until ovulation

30

Where is meiosis II arrested and until when?

Metaphase II until fertilization