Flashcards in Glomerular Disease Details Deck (65)
Signs of glomerulonephritis
Axotemia, oliguria, HTN, proteinuria
Acute Poststreptococcal GN Presentation
- 2-4 wks after Group A strep infection of pharynx or skin
- Peripheral or periorbital edema, cola-colored urine, HTN
- Positive strep titers/serologies, decreased complement levels due to consumption
Acute Poststreptococcal GN LM
Glomeruli enlarged and hypercellular
Acute Poststreptococcal GN IF
Granular appearance ("lumpy bumpy")
Due to IgG, IgM, and C3 deposition along GBM and mesangium
Acute Poststreptococcal GN EM
SUBEPITHELIAL IC humps
Acute Poststreptococcal GN Treatment
Usually resolves spontaneously, supportive rx
- Kids rarely progress to renal failure
- Some adults develop RPGN - only 60% of adult cases resolve completely (increased age --> poor px)
What type of HSN rxn is Acute Poststreptococcal GN?
Type III (Ab-Ag complexes)
Presentation of Rapidly Progressive (Crescentic) Glomerulonephritis
- Rapidly deteriorating renal function
- Poor px
Disease proceses that result in Rapidly Progressive (Crescentic) Glomerulonephritis?
- Granulomatosis with polyangiitis (Wegener)
- Microscopic polyangiitis
Presentation of Goodpasture?
Hematuria and hemoptysis
Type of HSN rxn is Goodpasture?
Type II HSN rxn (cytotoxic Ab mediated)
Pathogenesis of Goodpasture?
Ab to GBM and alveolar basement membrane (type IV collagen)
Presentation of Wegener's?
Nasopharynx + lungs + kidneys
Middle aged male
PR3-ANCA/c-ANCA (anti-proteinase 3)
Microscopic polyangiitis presentation
Lungs + kidneys + palpable purpura
NO nasopharyngeal involvement
Microscopic polyangiitis IF
Microscopic polyangiitis marker
Rapidly Progressive (Crescentic) Glomerulonephritis LM and IF?
- Cresent moon shape - consist of FIBRIN and plasma proteins (C3b) with glomerular parietal cells, monocytes, and MACS
Diffuse proliferative GN caused by?
SLE (common CoD)
Diffuse proliferative GN LM
"wire looping" of capillaries
Diffuse proliferative GN EM
SUBENDOTHELIAL and sometimes intramembranous IgG-based ICs
Often with C3 deposition
Diffuse proliferative GN IF
IgA Nephropathy (Berger DZ) presentation
- Episodic gross hematuria that occurs concurrently with respiratory or GI tract infections (IgA is secreted by mucosal lining)
What condition is IgA Nephropathy (Berger DZ) associated with?
Henoch-Schonlein Purpura (GI, kidneys, skin, joints)
IgA Nephropathy (Berger DZ) LM
IgA Nephropathy (Berger DZ) EM
Mesangial IC depositis