Flashcards in Oncology Deck (46)
What is biggest predictor of px in Hodgkin lymphoma?
Characteristic cell in Hodgkin lymphoma?
- "owl eyes"
- CD15+, CD30+
What virus is Hodgkin lymphoma associated with?
What virus is non-Hodgkin lymphoma associated iwth?
What type of Hodgkin lymphoma is more common in females? (All others are more common in males)
Nodular sclerosing type
Burkitt Lymphoma translocation?
- c-myc (TF that promotes cell growth)
Burkitt Lymphoma Buzz Words
- "Starry sky"
- "Tingible body mac"
- Jaw lesion in Africa
Most common type of non-Hodgkin lymphoma in adults?
Diffuse large B-cell lymphoma
Follicular Lymphoma translocation?
- BCL-2 (anti-apoptotic)
Mantle cell lymphoma translocation?
- Cyclin D1 (G1-->S)
Primary central nervous system lymphoma associated with...?
- Confusion, memory loss, seizures
- Mass lesions on MRI
Adult T-cell Lymphoma caused by?
HTLV (assoc. w/ IV drug use)
Presentation of adult t-cell lymphoma?
Cutaneous lesions - Japan, W Africa, Carribbean
- Lytic bone lesions, hypercalcemia
Mycosis Fungoides/Sezary Syndrome buzz words
Skin patches/plaques (cutaneous T cell lymphoma)
- Atypical CD4+ cells w/ "cerebriform" nuclei
Multiple Myeloma Ig
IgG or IgA
Associations of MM?
- Infection (decreased Ag diversity)
- Primary amyloidosis (AL)
- Punched out lytic bone lesions (activate RANKL R on osteoclasts - IL-1&6)
- M spike
- Ig light chains in urine (Bence Jones)
- Rouleaux formation
- M spike = IgM
- Hyperviscosity syndrome --> blurred vision, Raynaud
Neutrophils w/ bilobed nuclei
- Seen after chemo
Presentation of T-cell ALL?
Mediastinal mass (SVC-like syndrome)
ALL associated with what genetic mutation?
ALL peripheral blood smear/bone marrow?
- TdT+ (pre-T and pre-B cells)
- CD10+ (pre-B)
- CD10, 19, 20 = B
- CD2, 8 = T
ALL translocation associated with better px?
CLL peripheral blood smear?
- Smudge cells
- AI hemolytic anemia
SLL/CLL --> aggressive lymphoma (diffuse large B cell lymphoma)
Hairy Cell Leukemia bone marrow?
Marrow fibrosis --> dry tap on aspiration
Hairy cell leukemia Pdx?
Hairy cell leukemia stain?