Flashcards in Oncology Deck (46)
Loading flashcards...
1
What is biggest predictor of px in Hodgkin lymphoma?
Stage
2
Characteristic cell in Hodgkin lymphoma?
Reed-Sternberg cells
- "owl eyes"
- CD15+, CD30+
3
What virus is Hodgkin lymphoma associated with?
EBV
4
What virus is non-Hodgkin lymphoma associated iwth?
HIV
5
What type of Hodgkin lymphoma is more common in females? (All others are more common in males)
Nodular sclerosing type
6
Burkitt Lymphoma translocation?
t(8;14)
- c-myc (TF that promotes cell growth)
7
Burkitt Lymphoma Buzz Words
- "Starry sky"
- "Tingible body mac"
- EBV
- Jaw lesion in Africa
8
Most common type of non-Hodgkin lymphoma in adults?
Diffuse large B-cell lymphoma
9
Follicular Lymphoma translocation?
t(14;18)
- BCL-2 (anti-apoptotic)
10
Mantle cell lymphoma translocation?
t(11;14)
- Cyclin D1 (G1-->S)
11
Primary central nervous system lymphoma associated with...?
- HIV/AIDS
- Confusion, memory loss, seizures
- Mass lesions on MRI
12
Adult T-cell Lymphoma caused by?
HTLV (assoc. w/ IV drug use)
13
Presentation of adult t-cell lymphoma?
Cutaneous lesions - Japan, W Africa, Carribbean
- Lytic bone lesions, hypercalcemia
14
Mycosis Fungoides/Sezary Syndrome buzz words
Skin patches/plaques (cutaneous T cell lymphoma)
- Atypical CD4+ cells w/ "cerebriform" nuclei
15
Multiple Myeloma Ig
IgG or IgA
16
Associations of MM?
- Infection (decreased Ag diversity)
- Primary amyloidosis (AL)
- Punched out lytic bone lesions (activate RANKL R on osteoclasts - IL-1&6)
- M spike
- Ig light chains in urine (Bence Jones)
- Rouleaux formation
17
Waldenstrom Macroglobulinemia
- M spike = IgM
- Hyperviscosity syndrome --> blurred vision, Raynaud
18
Pseudo-Pelger-Huet Anomaly
Neutrophils w/ bilobed nuclei
- Seen after chemo
19
Presentation of T-cell ALL?
Mediastinal mass (SVC-like syndrome)
20
ALL associated with what genetic mutation?
Down Syndrome
21
ALL peripheral blood smear/bone marrow?
Increased lymphoblasts
22
ALL Markers?
- TdT+ (pre-T and pre-B cells)
- CD10+ (pre-B)
- CD10, 19, 20 = B
- CD2, 8 = T
23
ALL translocation associated with better px?
t(12;21)
24
CLL markers?
CD20+, CD5+
25
CLL peripheral blood smear?
- Smudge cells
- AI hemolytic anemia
26
Richter Transformation?
SLL/CLL --> aggressive lymphoma (diffuse large B cell lymphoma)
27
Hairy Cell Leukemia bone marrow?
Marrow fibrosis --> dry tap on aspiration
28
Hairy cell leukemia Pdx?
Massive splenomegaly
29
Hairy cell leukemia stain?
TRAP+
30
