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Flashcards in Oncology Deck (46)
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1

What is biggest predictor of px in Hodgkin lymphoma?

Stage

2

Characteristic cell in Hodgkin lymphoma?

Reed-Sternberg cells
- "owl eyes"
- CD15+, CD30+

3

What virus is Hodgkin lymphoma associated with?

EBV

4

What virus is non-Hodgkin lymphoma associated iwth?

HIV

5

What type of Hodgkin lymphoma is more common in females? (All others are more common in males)

Nodular sclerosing type

6

Burkitt Lymphoma translocation?

t(8;14)
- c-myc (TF that promotes cell growth)

7

Burkitt Lymphoma Buzz Words

- "Starry sky"
- "Tingible body mac"
- EBV
- Jaw lesion in Africa

8

Most common type of non-Hodgkin lymphoma in adults?

Diffuse large B-cell lymphoma

9

Follicular Lymphoma translocation?

t(14;18)
- BCL-2 (anti-apoptotic)

10

Mantle cell lymphoma translocation?

t(11;14)
- Cyclin D1 (G1-->S)

11

Primary central nervous system lymphoma associated with...?

- HIV/AIDS
- Confusion, memory loss, seizures
- Mass lesions on MRI

12

Adult T-cell Lymphoma caused by?

HTLV (assoc. w/ IV drug use)

13

Presentation of adult t-cell lymphoma?

Cutaneous lesions - Japan, W Africa, Carribbean
- Lytic bone lesions, hypercalcemia

14

Mycosis Fungoides/Sezary Syndrome buzz words

Skin patches/plaques (cutaneous T cell lymphoma)
- Atypical CD4+ cells w/ "cerebriform" nuclei

15

Multiple Myeloma Ig

IgG or IgA

16

Associations of MM?

- Infection (decreased Ag diversity)
- Primary amyloidosis (AL)
- Punched out lytic bone lesions (activate RANKL R on osteoclasts - IL-1&6)
- M spike
- Ig light chains in urine (Bence Jones)
- Rouleaux formation

17

Waldenstrom Macroglobulinemia

- M spike = IgM
- Hyperviscosity syndrome --> blurred vision, Raynaud

18

Pseudo-Pelger-Huet Anomaly

Neutrophils w/ bilobed nuclei
- Seen after chemo

19

Presentation of T-cell ALL?

Mediastinal mass (SVC-like syndrome)

20

ALL associated with what genetic mutation?

Down Syndrome

21

ALL peripheral blood smear/bone marrow?

Increased lymphoblasts

22

ALL Markers?

- TdT+ (pre-T and pre-B cells)
- CD10+ (pre-B)
- CD10, 19, 20 = B
- CD2, 8 = T

23

ALL translocation associated with better px?

t(12;21)

24

CLL markers?

CD20+, CD5+

25

CLL peripheral blood smear?

- Smudge cells
- AI hemolytic anemia

26

Richter Transformation?

SLL/CLL --> aggressive lymphoma (diffuse large B cell lymphoma)

27

Hairy Cell Leukemia bone marrow?

Marrow fibrosis --> dry tap on aspiration

28

Hairy cell leukemia Pdx?

Massive splenomegaly

29

Hairy cell leukemia stain?

TRAP+

30

Hairy cell leukemia treatment?

Cladribine, pentostatin