Oncology

Question 1

What is biggest predictor of px in Hodgkin lymphoma?

Answer 1

Stage

Question 2

Characteristic cell in Hodgkin lymphoma?

Answer 2

Reed-Sternberg cells

• “owl eyes”
• CD15+, CD30+

Question 3

What virus is Hodgkin lymphoma associated with?

Answer 3

EBV

Question 4

What virus is non-Hodgkin lymphoma associated iwth?

Answer 4

HIV

Question 5

What type of Hodgkin lymphoma is more common in females? (All others are more common in males)

Answer 5

Nodular sclerosing type

Question 6

Burkitt Lymphoma translocation?

Answer 6

t(8;14)

- c-myc (TF that promotes cell growth)

Question 7

Burkitt Lymphoma Buzz Words

Answer 7

• “Starry sky”
• “Tingible body mac”
• EBV
• Jaw lesion in Africa

Question 8

Most common type of non-Hodgkin lymphoma in adults?

Answer 8

Diffuse large B-cell lymphoma

Question 9

Follicular Lymphoma translocation?

Answer 9

t(14;18)

- BCL-2 (anti-apoptotic)

Question 10

Mantle cell lymphoma translocation?

Answer 10

t(11;14)

- Cyclin D1 (G1–>S)

Question 11

Primary central nervous system lymphoma associated with…?

Answer 11

• HIV/AIDS
• Confusion, memory loss, seizures
• Mass lesions on MRI

Question 12

Adult T-cell Lymphoma caused by?

Answer 12

HTLV (assoc. w/ IV drug use)

Question 13

Presentation of adult t-cell lymphoma?

Answer 13

Cutaneous lesions - Japan, W Africa, Carribbean

- Lytic bone lesions, hypercalcemia

Question 14

Mycosis Fungoides/Sezary Syndrome buzz words

Answer 14

Skin patches/plaques (cutaneous T cell lymphoma)

- Atypical CD4+ cells w/ “cerebriform” nuclei

Question 15

Multiple Myeloma Ig

Answer 15

IgG or IgA

Question 16

Associations of MM?

Answer 16

• Infection (decreased Ag diversity)
• Primary amyloidosis (AL)
• Punched out lytic bone lesions (activate RANKL R on osteoclasts - IL-1&6)
• M spike
• Ig light chains in urine (Bence Jones)
• Rouleaux formation

Question 17

Waldenstrom Macroglobulinemia

Answer 17

• M spike = IgM

- Hyperviscosity syndrome –> blurred vision, Raynaud

Question 18

Pseudo-Pelger-Huet Anomaly

Answer 18

Neutrophils w/ bilobed nuclei

- Seen after chemo

Question 19

Presentation of T-cell ALL?

Answer 19

Mediastinal mass (SVC-like syndrome)

Question 20

ALL associated with what genetic mutation?

Answer 20

Down Syndrome

Question 21

ALL peripheral blood smear/bone marrow?

Answer 21

Increased lymphoblasts

Question 22

ALL Markers?

Answer 22

• TdT+ (pre-T and pre-B cells)
• CD10+ (pre-B)
• CD10, 19, 20 = B
• CD2, 8 = T

Question 23

ALL translocation associated with better px?

Answer 23

t(12;21)

Question 24

CLL markers?

Answer 24

CD20+, CD5+

Question 25

CLL peripheral blood smear?

Answer 25

- Smudge cells | - AI hemolytic anemia

Question 26

Richter Transformation?

Answer 26

SLL/CLL --> aggressive lymphoma (diffuse large B cell lymphoma)

Question 27

Hairy Cell Leukemia bone marrow?

Answer 27

Marrow fibrosis --> dry tap on aspiration

Question 28

Hairy cell leukemia Pdx?

Answer 28

Massive splenomegaly

Question 29

Hairy cell leukemia stain?

Answer 29

TRAP+

Question 30

Hairy cell leukemia treatment?

Answer 30

Cladribine, pentostatin

Question 31

AML Buzzwords

Answer 31

- AUER RODS - Myeloperoxidase + - Increased circulating myeloblasts

Question 32

RF for AML?

Answer 32

- Alkylating chemo - Radiation - Myeloproliferative disorders - Down syndrome

Question 33

APL Translocation?

Answer 33

t(15;17) - responds to all-trans retinoic acid (vit A) | - Presents as DIC

Question 34

CML Translocation?

Answer 34

- t(9;22) = BCR-ABL (TK)

Question 35

CML buzz word?

Answer 35

Basophilia

Question 36

CML rx?

Answer 36

Imatinib (TK inhibitor)

Question 37

Presentation of Langerhans cell histiocytosis?

Answer 37

- Lytic bone lesions - skin rash - Recurrent otitis media w/ mass involving mastoid bone

Question 38

Langerhans cell histiocytosis markers?

Answer 38

S-100, CD1a | Birbeck granules

Question 39

Chronic Myeloproliferative Disorder Mutation

Answer 39

V617F JAK2 mutation (cytoplasmic TK)

Question 40

Polycythemia Vera presentation

Answer 40

- INTENSE ITCHING AFTER HOT SHOWER | - Erythromelagia (seere, burning pain and red-blue coloration)

Question 41

Polycythemia vera rx?

Answer 41

Aspirin

Question 42

Polycythemia vera labs?

Answer 42

Decreased EPO Increased hematocrit Increased RBCs, WBCs, Platelets

Question 43

Polycythemia vera association?

Answer 43

Budd Chiari

Question 44

Essential thrombocythemia characterized by...?

Answer 44

- Massive proliferation of megakaryocytes and platelets | - Increased platelets

Question 45

Myelofibrosis ?

Answer 45

Increased fibroblast activity --> obliteration of bone marrow with fibrosis - Massive splenomegaly - Teardrop RBCs - Decreased RBCs

Question 46

What malignancies produce ectopic EPO?

Answer 46

RCC | HCC