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Flashcards in Vasculitides Deck (39)
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1

Complication of giant cell (temporal) arteritis?
- Elderly female > 50
- Unilateral HA, jaw claudication, flu-like sx

BLINDNESS (ophthalmic artery occlusion)

2

What condition is giant cell (temporal) arteritis associated with?

Polymyalgia rheumatica

3

What artery is giant cell (temporal) arteritis associated with?

Branches of carotid --> temporal

4

giant cell (temporal) arteritis bx shows?

Focal granulomatous inflammation (segmental)

5

giant cell (temporal) arteritis labs?

Elevated ESR

6

giant cell (temporal) arteritis Rx?

Corticosteroids to prevent blindness

7

What do people call Takayasu arteritis?
- Asian females

"Pulseless DZ" - weak UE pulses

8

Takayasu arteritis bx?

Granulomatous thickening

9

What artery is involved with Takayasu arteritis?

Aortic arch and proximal great vessels

10

Takayasu arteritis labs?

Elevated ESR

11

Takayasu arteritis Rx?

Corticosteroids

12

What infection is polyarteritis nodosa associated with?
- Young adult male
- Fever, weight loss malaise, HA
- Abdominal pain, melena
- HTN, neuro dysfunction, cutaneous eruptions, renal damage

Hepatitis B

13

What vessels does polyarteritis nodosa involve?

Renal and visceral vessels
NOT pulmonary arteries (lungs are spared)

14

Pathogenesis of polyarteritis nodosa?

Immune complex mediated

15

polyarteritis nodosa bx?

Transmural inflammation of arterial wall with fibrinoid necrosis
- Different stages of inflammation in different vessels

16

polyarteritis nodosa arteriogram?

Innumerable renal microaneurysms and spasms

17

polyarteritis nodosa rx?

Corticosteroids, cyclophosphamide

18

Kawasaki Disease presentation?

Asian children

19

Complication of Kawasaki?

Coronary artery aneurysms

20

Kawasaki rx?

IV Ig and aspirin

21

Presentation of Buerger DZ?

Male

22

Complications of Buerger DZ?

- Gangrene, autoamputation of digits, superficial nodular phlebitis

23

Buerger DZ bx?

Segmental thrombosing vasculitis

24

Buerger DZ treatment?

Smoking cessation

25

Wegener's Granulomatosis with polyangiitis presentation

Middle aged male
- URT: perforation of nasal septum, chronic sinusitis, otitis media, mastoiditis
- LRT: hemoptysis, cough, dyspnea
- Renal: hematuria, RBC casts

26

Wegener's Granulomatosis with polyangiitis triad?

- Focal necrotizing vasculitis
- Necrotizing granulomas in the lung and upper airway (giant cells)
- Necrotizing GN

27

Wegener's Granulomatosis with polyangiitis marker?

c-ANCA (PR3-ANCA) - antiproteinase 3 (neutrophil)

28

Wegener's Granulomatosis with polyangiitis CXR?

Large nodular densities

29

Wegener's Granulomatosis with polyangiitis Rx?

Cyclophosphamide, corticosteroids

30

Microscopic polyangiitis presentation?

Like Wegener's but no URT involvement