Gluconeogenesis Flashcards Preview

Biochem block 3 > Gluconeogenesis > Flashcards

Flashcards in Gluconeogenesis Deck (11):
1

what are the 2 organs that perform gluconeogenesis?

Liver (mostly)
kidney (prolonged fast)

2

glycerol is released from hydrolysis of TAGs and converted into what?

DHAP

3

What is the cori cycle?

glucose to lactate through anaerobic glycolysis
to the liver
lactate converted back to glucose
released back to circulation

4

amino acids (specifically Alanine) for gluconeogenesis are derived from what source?

hydrolysis of muscle proteins

5

Acetyl CoA can be converted into pyruvate in humans. T or F?

FALSE

6

what regulator found in both glycolysis and gluconeogenesis has opposite effects and keeps the pathways exclusive?

fructose 2-6-BP

7

How does glucagon affect fructose 2,6-BP?

inhibits PFK-2
lowers fructose 2,6-BP
activates gluconeogenesis

8

how does glucagon affect PEP?

inhibits pyruvate kinase
PEP is used for gluconeogenesis instead of glycolysis

9

how do glucagon and insulin affect PEPCK?

insulin- inhibits
glucagon- stimulates

10

where does the energy for gluconeogenesis come from?

oxidation of fatty acids in the liver

11

what does a build up of acetyl CoA signal to pyruvate carboxylase?

OAA is being diverted for gluconeogenesis, not TCA cycle