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Flashcards in Gonadal hormones Deck (88)
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31

ethinyl estradiol MOA

stimulation of estrogen receptors = change rate of transcription

relies on P450

32

ethinyl estradiol use

prevent osteoporosis
HRT
OCP
hypogonadism

33

ethinyl estradiol AE

breakthrough bleeding
thromboembolism
gallbladder diz
hyperTG
HTN
depression

post menopausal women: breast CA, endometrial hyperplasia

**pro-thrombotic drug - blocks AT3

taken with p450 inducer = breakthrough bleeding, dec contraceptive efficacy

34

mestranol

prodrug - converted to ethinyl estradiol

35

dietthlstilbestrol

nonsteroidal estrogen agonist used in pregnancy -- can lead to infertility and vaginal cancer

36

estrogen esters

long acting estrogens - given IM and used for hypogonadism in young females

37

weekly patch

ethinyl estradiol + norelgestromin

38

monthly vaginal ring

ethinyl estradiol + etonogestrel

39

IUD

L-norgestrel

40

subcutaneous implant

etonogestrel

41

depot IM

medroxyprogesterone

42

postcoital contraceptive

L-norgestrel, combined oral contraceptive

43

tx for intractable dysmenorrhea

conjugated estrogens
ethinyl estradiol
OCP
depot inejction
GnRH agnoist

44

infertility tx

progesterone*
clomiphene
hMG and hCG
GnRH analogs
bromocriptine

45

endometriosis tx

OCP
depot injection
GnRH agonist
danazol

46

osteoporosis in postmenopausal women

conjugated estrogens
estradiol
raloxifene

47

hirsutism

combined OCP
spirinolactone
flutamide
GnRH agonist

48

progesterone functions

stimulate endometrial glandular secretion

pro-gestation
dec myometrial contraction

inc body temp

thick cervical mucus

prevent endometrial hyperplasia

49

norgestrel AE

weight gain
dec in bone density

**low HDL, inc LDL, HTN**

50

drospirenone

progestin of spironolactone derivative

51

tamoxifen

SERM - estrogen antag at breast and CNS. agonist in endometrium, liver and bone

52

tamoxifen AE

hot flush
thromboembolism
endometrial hyperplasia

53

raloxifene vs tamoxifene

protect against osteoporosis
antagonist effects in breast and CNS and endomterium

**bone density increases with raloxifene

54

clomiphene

induced ovulation
ER antagonist effect in pituitary = gonadotropin secretion increased

55

clomiphene AE

hyperstimulation of ovary = hypertrophy

multiple pregnancy

hot flush, n/v, weight gain

56

fulvestrant MOA

estrogen antagonist in all tissues = SERD

57

fulvestrant use

tx for hormone responsive breast CA that is resistant to first lines

IM admin

58

fulvestrant AE

hot flush, HA, injection site reactions

59

anastrozole MOA

inhibits aromatase = dec estrogen synthesis

60

anastrozole use

tx for hormone responsive breast CA

oral admin