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Flashcards in Gonadal hormones Deck (88)
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61

anastrozole AE

musculoskeletal disorder, dec bone density, hot flushes

joint sxs: spondylosis, osteoarhtritis, disk herniation

62

letrozole

similar to anastrozole

63

exemestane

irreversible aromatase inhibitor

64

leuprolide use

ovarian suppresion
control ovarian hyperstimulation
central precocious puberty
block endogenous puberty in transgender
adv prostate cancer

65

Leuprolide AE

continued use - may show signs of hypogonadism
light headed, HA, nausea

66

GnRH analogs

goserelin
histrelin
nafarelin
triptorelin
gonadorelin

67

ganirelix MOA

GnRH antagonist

68

ganirelix use

prevention of premature LH surges during controlled ovulation hyperstimulation

69

cetrorelix

similar to ganirelix

70

degarelix

used for adv prostate CA

71

Danazol

partial agonist of progestin and androgen receptors

*p450 inhibtior

72

danazol use

endometriosis
fibrocystic breast

73

danazol AE

acne
hirsutism
weight gain
menstrual disturbance

74

mifepristone

antiprogestin
progestin and glucocorticoid blocker

75

mifepristone use

abortion

76

dihydrotestosterone vs testosterone vs androstenedione - potency?

DHT most potent

77

what drug is used for wasting syndromes?

testosterone - helps with weight gaining

78

oral testosterone

fluoxymesterone
methyltestosterone

79

long acting androgens for parenteral admins

testosterone esthers

80

finasteride use

BPH
male patterned hair loss

oral admin

81

finasteride AE

impotence
gynecomastia

82

dutasteride

similar to finasteride

83

flutamide MOA

competitive inhibition of androgen receptor

84

flutamide use

adv prostate cancer

85

flutamide AE

gynecomastia
hot flush
impotence
hepatotoxicity

86

bicalutamide

flutamide like - lower liver toxicity risk

87

nilutamide

flutamide like - lower liver toxicity risk

88

cyproterone

used in hirsutism and to decrease excessive sexual drive in men