Hematology Flashcards Preview

USMLE step2 > Hematology > Flashcards

Flashcards in Hematology Deck (41):
1

Aplasic anemia related drugs
Can Make New Blood Cels Properly

carbamazepine
metimazol
Nsaids
Benzeno
cloranfenicol
propylthiouracyl

2

ALL treatment adults and kids

Adults: CAVD
-cyclofosfamida
-adriamicina
-vincristina
-dexamentasona
KIDS: DVP
-daunorrubicina
-vincristina
-Prednisona

3

tyrosine kinase inhibitors

CML treatment:
-nilotinib
-nasatinib
-imatinib

4

iron deficiency RDW vaile

RDW its increased

5

thalassima has elevelated

reticulocytes(only 3-gene deletion)
Hg H

6

first step in macrocytic anemia

peripheral smear

7

methylmalonic acid elevation

B12 deficiency

8

spherocytes DDx

Autoinmune hemolysis: coombs +
spherocytosis: coombs -

9

causes of Autoinmune Hemolysis
(warm or IgG)

CLL
Lymphoma
SLE
Drugs:
-penicillin
-alpha mehyl dopa
-rifampin
-phenyotin

10

cold agglutinin disease association

EBV
waldenstrom macroglobulinemia
Mycoplasmas Pneumoniae

11

TTP cause and treatment

ADAMTS 13 deficiency
treat with plasmapheresis

12

aplastic anemia treatmet

50 years old

50 years old
-antithymocyte globulin and cyclosporine

alemtuzumab(anti cd52)

13

tumor lysis syndrome prophylaxis

allopurinol and rasburicasae

14

most effective treatment for CML

blood marrow transplant

15

pancytopenia with increased MCV, nucleated red cells,

myelodysplastic syndrome

16

5q deleteion on MDS

give lenalidomide

17

pelger-huet cells

bilobulated neutrophils assoaciated with MDS

18

CLL stages and treatmen

stage 0=elevated WBC
stage 1= lymphadenopathy
stage 2=hepatosplenomegaly
stage3=anemia
stage4=thrombocytopenia

TREAT STAGE 3 and 4 or symptomatic:
-fludrarabine
-cyclophosphamide
-rituximab

19

HCL CD and treatment

CD11c
cladribine or pentostatin

20

best inital step for NHL

excisional biopsy

21

NHL treatment

LOCAL DISEASE=radio and chemo
-ADVANCED DISEASE=stage III and IV any B symptoms
CHOP + rituximab (cyclophosphamide,hydroxydaunorubicin,oncovin,predni)

22

hodgkin disease treatment

ABVD
-Adriamycin
-Bleomycin
-vinblastine
-Dacarbazine

23

Myeloma multiple AB

IgG and IgA

24

first step in myeloma

Xray of affected bone

25

most common cause of dead in myeloma

renal failure and infection

26

most effective treatment for myeloma in pt under 70

autologos bone marrow transplant

27

myeloma inital treatmen

DEXAMETHASONE with lenalidomide,bortezomib or both

28

waldenstrom macroglobulinemia

IgM hyperviscosity sign
treat with plasmapheresis.

29

ITP treatmetn

steroids
severe bleeding(GI/CNS)IVIG, anti rho
recurrent episodes==>splenectomy

30

pancytopenia

-aplastic anemia(fat in marrow)
-acute leukemia(blast in marrow)
-MDS(normal bonemarrow)

31

when to give packed red blood cells

-if patient is symtomatic
-hematocrit below 30 in elderly or one with heart disease

32

ora iron chelators

deferiprone and deferasirox

33

what lower mortality in sickle cell disease

-hydroxyurea in prevention
-antibiotics with fever

34

TTP associations

-ticlopidine
-clopidogrel
-cyclosporine
-AIDS
-SLE

35

single most accurate test for myeloma

bone marrow biopsy ALWAYS do it after induction chemo with lenalinomide and steroids

36

hemolytic anemias

-siclke cell disease(reticulocyte always high)
-hereditary spherocytosis
-autoinmune hemolysis
-cold agglutinin disease
-G6PD deficinecy
-HUS and TTP
-paroxystical nocturnal hematuria

37

most accurate test for polycythemia vera

test for JAK2

38

most acurate test for acute leukemia

flow cytometry

39

most acurate test for CML

PCR or FISH look for BCR-ABL mutation

40

most common NHL

difuse large B-cell (14;18)

41

treatment of HIT

step heparin
give: fondaparinux,argatroban,lepirudin,bivalirudin