Hematology

Question 1

Aplasic anemia related drugs

Can Make New Blood Cels Properly

Answer 1

carbamazepine
metimazol
Nsaids
Benzeno
cloranfenicol
propylthiouracyl

Question 2

ALL treatment adults and kids

Answer 2

Adults: CAVD
-cyclofosfamida
-adriamicina
-vincristina 
-dexamentasona
KIDS: DVP
-daunorrubicina
-vincristina
-Prednisona

Question 3

tyrosine kinase inhibitors

Answer 3

CML treatment:

• nilotinib
• nasatinib
• imatinib

Question 4

iron deficiency RDW vaile

Answer 4

RDW its increased

Question 5

thalassima has elevelated

Answer 5

reticulocytes(only 3-gene deletion)

Hg H

Question 6

first step in macrocytic anemia

Answer 6

peripheral smear

Question 7

methylmalonic acid elevation

Answer 7

B12 deficiency

Question 8

spherocytes DDx

Answer 8

Autoinmune hemolysis: coombs +

spherocytosis: coombs -

Question 9

causes of Autoinmune Hemolysis

warm or IgG

Answer 9

CLL
Lymphoma
SLE
Drugs:
-penicillin
-alpha mehyl dopa
-rifampin
-phenyotin

Question 10

cold agglutinin disease association

Answer 10

EBV
waldenstrom macroglobulinemia
Mycoplasmas Pneumoniae

Question 11

TTP cause and treatment

Answer 11

ADAMTS 13 deficiency

treat with plasmapheresis

Question 12

aplastic anemia treatmet

50 years old

Answer 12

50 years old
-antithymocyte globulin and cyclosporine

alemtuzumab(anti cd52)

Question 13

tumor lysis syndrome prophylaxis

Answer 13

allopurinol and rasburicasae

Question 14

most effective treatment for CML

Answer 14

blood marrow transplant

Question 15

pancytopenia with increased MCV, nucleated red cells,

Answer 15

myelodysplastic syndrome

Question 16

5q deleteion on MDS

Answer 16

give lenalidomide

Question 17

pelger-huet cells

Answer 17

bilobulated neutrophils assoaciated with MDS

Question 18

CLL stages and treatmen

Answer 18

stage 0=elevated WBC
stage 1= lymphadenopathy
stage 2=hepatosplenomegaly
stage3=anemia
stage4=thrombocytopenia

TREAT STAGE 3 and 4 or symptomatic:

• fludrarabine
• cyclophosphamide
• rituximab

Question 19

HCL CD and treatment

Answer 19

CD11c

cladribine or pentostatin

Question 20

best inital step for NHL

Answer 20

excisional biopsy

Question 21

NHL treatment

Answer 21

LOCAL DISEASE=radio and chemo
-ADVANCED DISEASE=stage III and IV any B symptoms
CHOP + rituximab (cyclophosphamide,hydroxydaunorubicin,oncovin,predni)

Question 22

hodgkin disease treatment

Answer 22

ABVD

• Adriamycin
• Bleomycin
• vinblastine
• Dacarbazine

Question 23

Myeloma multiple AB

Answer 23

IgG and IgA

Question 24

first step in myeloma

Answer 24

Xray of affected bone

Question 25

most common cause of dead in myeloma

Answer 25

renal failure and infection

Question 26

most effective treatment for myeloma in pt under 70

Answer 26

autologos bone marrow transplant

Question 27

myeloma inital treatmen

Answer 27

DEXAMETHASONE with lenalidomide,bortezomib or both

Question 28

waldenstrom macroglobulinemia

Answer 28

IgM hyperviscosity sign | treat with plasmapheresis.

Question 29

ITP treatmetn

Answer 29

steroids severe bleeding(GI/CNS)IVIG, anti rho recurrent episodes==>splenectomy

Question 30

pancytopenia

Answer 30

- aplastic anemia(fat in marrow) - acute leukemia(blast in marrow) - MDS(normal bonemarrow)

Question 31

when to give packed red blood cells

Answer 31

- if patient is symtomatic | - hematocrit below 30 in elderly or one with heart disease

Question 32

ora iron chelators

Answer 32

deferiprone and deferasirox

Question 33

what lower mortality in sickle cell disease

Answer 33

- hydroxyurea in prevention | - antibiotics with fever

Question 34

TTP associations

Answer 34

- ticlopidine - clopidogrel - cyclosporine - AIDS - SLE

Question 35

single most accurate test for myeloma

Answer 35

bone marrow biopsy ALWAYS do it after induction chemo with lenalinomide and steroids

Question 36

hemolytic anemias

Answer 36

- siclke cell disease(reticulocyte always high) - hereditary spherocytosis - autoinmune hemolysis - cold agglutinin disease - G6PD deficinecy - HUS and TTP - paroxystical nocturnal hematuria

Question 37

most accurate test for polycythemia vera

Answer 37

test for JAK2

Question 38

most acurate test for acute leukemia

Answer 38

flow cytometry

Question 39

most acurate test for CML

Answer 39

PCR or FISH look for BCR-ABL mutation

Question 40

most common NHL

Answer 40

difuse large B-cell (14;18)

Question 41

treatment of HIT

Answer 41

step heparin | give: fondaparinux,argatroban,lepirudin,bivalirudin