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Flashcards in Hematology l Deck (28)
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1

what is TIBC
if high
if low

% transferrin saturation; total iron binding capacity
high - iron xu anemia, pregN
low - anemia of chronic dz, sideroblastic anemia, hemochromatosis

2

ferritin elevates during when

inflamma and cancer

3

right shift can be due to

b12 olae xu, hypersegmentation of neutrophils

4

MCV low =

iron xu, thalassemia, lead poisoning

5

microcytic hypochromic anemia dt

iron xu, severe protein xu, thal, chroic infx

6

normocytic normochronic anemia dt

loss of blood or loss of blood production
- then look at reticulocytes

7

Hemochromatosis is usu dx at what age?
complications

middle aged
LR failure, pancreatic failure

8

Henoch Schonlein purpura
age
presentation

children < 10 yo
usu acute URI precedes it
IgA in small vessels and joints
1. RASH 2. ABD PAIN OR RENAL 3. ARTHRITIS ... see bruising on areas of pressure like buttocks

9

thrombotic thrombocytopenic purpura, TTP
presentation

FATAL DIE AT 40yo
vWF cleaving protease inhibited
clotting in small vessels so decrease in plt

10

Dx TTP

microangiopathic hemolytic anemia
schistocytes, helmet cells
increase LDH
mental status or focal neuro deficits

11

Hemolytic Uremic Syndrome
presentation

toxin, bacteria or drug causes hemolytic anemia ---> blocking fxn of KD so failure there and build up of UREMIC acid

12

von Willebrand Dz

labs normal, so have to do clotting studies
either see light to heavy bleeding depending on genetics - many never diagnosed

13

DIC

usu ACUTE like complications obstetrics, infxn, malign - when all clotting factors are used up

14

Hemophilia A vs B

x-linked recessive
A = 8 factor
B = 9 factor; peds, dx factor 9 assay, tx FFP

15

Polycythemia vera vs Reactive Polycthemia

PVera - is true, ITCHY AFTER BATH, easy bruising bleeding; high RBC

16

MC ETIC OF Reactive POLYCYTHEMIA

emphysema dt increase in erythropoietin
other eti: renal, tumor, tetralogy of fallot

17

Leukemia vs Lymphoma

leukemia - SP & LR enlarged
lymphoma - LA

18

Multiple Myeloma
age
presentation

> 50 yo
IgG or IgA is jumbled in attacking a neoplastic plasma cell
SSx: bone back pain, fractures, bleeding agg of arrhythmias
BENCE JONES PROTEINURIA
PUNCHED OUT BONE LESIONS

19

BENCE JONES PROTEINURIA

MM, Waldenstrom's Macroglobulinemia

20

PUNCHED OUT BONE LESIONS

MM

21

Waldenstroms Macroglobulinemia

> 50 yo, B lymphocytes & IgM

22

Types of Leukemias, age, prognosis

ALL - mc in children, F, bone pain, hepatosplenomegaly, 90% cure
AML - older children 15-39 yo, worse progN, splenomegaly
CML - 45 yo, any cell affected, chronic, remit and relapse, PHILADELPHIA CHROMOSOMES
CLL - > 55 yo, no sxs at first, see super high WBC 50-250,000, progn good

23

AUER RODS

AML

24

PHILADELPHIA CHROMOSOMES

CML

25

Single node that spreads

Hodgkin's lymphoma

26

Hodgkin's lymphoma

single node that spreads
intermittent spiking F

27

Non-Hodg vs Hodg - which worse?

Non-Hodg - no age limits too

28

Burkitt's Lymphoma
presentation
complications

B-lymphocytes
LA in maxilla or mandible
can lead to Non-Hodgkins