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Flashcards in Misc Deck (23)
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1

Barbituates and what CI because why?

Barbs & Estrogen (OCP)
p450 enzyme inducer - pregN

2

Steroids & what CI because why?

steroids and MAO-I
compete for p450 so risk of overdose

3

Aspirin & what CI

if have gout, aspiring is CI because can cause increase in uric acid

4

GFR level - when to make adjustments in medications

< 60

5

Zero Order Elimination

once enzymes are saturated, the drug is excreted at a constant amt per unit time
vs First-Order Elimination - by %

6

Aminoglycosides SE

ototoxicity

7

Acetominophen Antidote

NAC

8

Opiate antidote

naloxone

9

Benzo antidote

Flumazenil

10

Cyanide antidote

amyl nitrate

11

Organophosphate antidote

atropine, pralidoxine

12

Iron antidote

deferoxamine

13

Heparin antidote

protamine

14

ACh-r are what?

nicotinic muscarinic

15

Acetycholine metabolism by what enzyme? what inhibits this enzyme?

acetylcholine esterase
bug killers --> tetany, cramps

16

Adrenergic receptors are

alpha 1,2 beta 1,2
EPI, NE

17

Cholinergic means

acts like ACh

18

What does rauwolfia do?

decreases catcholamines (NE, SE) reserpine

19

Chincona bark creates two drugs:

alkaloids
Quinine - anti-spasm, anti-pyr
Quinidine - antiarrthym (anticholinergic)

20

Papaver

papaverine - alkaloid
vasodilation
tx angina
analgesic, blocks parasym

21

Claviceps

ergot fungi
vasoconstrictive
bromocriptine - dopamine agonist

22

Calabar

bean / physostigma
inhibits Ach esterase, so more ACh
parasympathomimetic

23

Pylocarpus

cholinergic
parasympathomimetic
tx glaucoma (pupil constrict)