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Flashcards in Pharm ll Deck (60)
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1

Carbidopa MOA

inhibits Dopa Decarboxylase
- levodopa is the substrate for more dopamine
- Cat C
- indic parkinson's

2

2 Dopamine agonist for Parkinson's

Pramipexole, Bromocriptine

3

Bromocriptine indic, ADR

PD, pituitary tumors, acromegaly
SE: pulmonary fibrosis

4

Anticholinergic indic for PD
if this drug doesn't work, use what?

Benztropine
if not work, diphenhydramine

5

Amantadine MOA

antagonizes excitatory NMDA receptors
indic: levodopa induced dyskinesias; influenza-A (rarely)
ADR: exacerbate mental illness, insomnia, hallucinations, NMS

6

Scopolamine indic

N/V assoc w motion sickness, muscle spasms, Parkinson's like conditions (muscles)

7

2 drugs for weight loss
MOA
preg Cat

dextroamphetamine
phentermine
MOA: release of Dopa, NE
Phentermine is Cat X

8

Strattera name

Atomoxatine
indic ADHD
suicidal ideation

9

Modafinil SE

SJS, rash, hypertension, etc

10

Drugs indic fo MS

glatiramer acetate, fingolimod, interferon beta 1, baclofen, tizanidine

11

Glatiramer acetate
MOA
INDIC
WARNINGS

L-GLUTAMIC ACID POLYMER
MOA is unknown
Immune Modulator (down regulates myelin antigens)
INDIC: MS
WARNING: hypersensitivity
CAT B

12

Fingolimod
MOA
INDIC
CI

sphingosine 1-phosphate R modulator
MOA: blocks lymphocytes from emerging from lymph nodes
INDIC: MS
CI: concurrent use of class 1a or lll antiarrhythmic

13

3 drugs for muscle spasticity

botulinum: ACh release inhibitor
baclofen: MOA unknown, not indicated for stroke, must TAPER OFF (hallucinations/seizures)
tizanidine: alpha 2 adrenergic agonist (centrally) - cause sedation

14

2 anti-seizure meds
MOA: NA channel inhibitors
CAT

carbamazepine, phenytoin
- sodium channel inhibitors
- CAT D

15

Phenytoin SE

gingival hyperplasia, suicidal behavior

16

GABA analogs indic anti-seizures

Gabapentin, Pregabalin
ADR: suicidal behavior, LR toxicity
CAT C

17

Valproate INDIC

anti-convulsant, epilepsy, mania, migraine
SE: suicide

18

Lamotrigine INDIC

epilepsy, bipolar
SE: skin rashes, suicide
CAT C

19

Atypical Antipsychotics

Risperidone
Quetiapine
Aripiprazole
MOA unknown
SCHIZO
SE: dyslipidemia, dysglycemia, compulsive urges, suicide
increased mortality in elderly
CLOZAPINE

20

Clozapine SE

increased mortality in elderly, severe neutropenia, ortho hypo, bradyca, syncope, seizure, myocarditis, cardiomyopathy

21

MAO-I have man drug interactions because

CYP450

22

Thalidomide

immunomodulatory
indic: leprosy, Multiple myeloma
CT: X

23

Tofacitinib

JAK inhibitor
DMARD
BB: future CA, risk of fatal infxn
INDIC: RA

24

DMARDs

methotrexate (folate analogue)
sulfasalazine (reduces folate/prodrug of antibiotic)
hydroxychloroquine (SLE, RA, anti-malarial)
penacillamine (Wilson's Dz, RA, slows joint deformation)
tofacitinib (JAK inhib)

25

Etancercept

cytokine inhibitor
RA, JA, Psor Arth, plaq psor, AS

26

Adalimumab
Infliximab

cytokine inhibitors
TNF-alpha blocker (-mabs)
inc risk of serious infn

27

2 drugs for transplants

Cyclosporine
Tacrolimus

28

2 alkylating agents for chemo

cisplatin
cyclophosphamide

29

1 anthracycline for chemo

doxorubicin

30

Anti-Her-2 chemo

trastuzumab